FIG. 3.

Mean (±SEM) % accuracy in the left (A), center (B), and right (C) cue port holes averaged for the last three baselines (BSL) at the 2 s cue and then each day of 3-CSRT testing post-surgery. Statistical analysis of BSL performance revealed that there were no significant differences in % accuracy across the cue ports and among groups prior to surgery indicating a lack of spatial bias. (A) Following TBI, pronounced % accuracy deficits to the left cue port are suggestive of hemi-spatial neglect of the left visual field contralateral to the injury site. GAL did not restore TBI-induced deficits of sustained attention, relative to VEH, and the higher dose of GAL (5.0 mg/kg) exacerbated attentional impairments. (B) Assessment of the center % accuracy indicates that post-injury GAL administration regardless of dose was associated with inferior attentional performance. (C) TBI induced significant attentional impairments to the right cue port, which were exacerbated by TBI + GAL (5.0 mg/kg). ^#p < 0.05, SHAM vs. TBI + VEH and TBI + GAL (0.5, 2.0, and 5.0 mg/kg). *p < 0.05, TBI + GAL (5.0 mg/kg) vs. TBI + VEH and TBI + GAL (0.5 and 2.0 mg/kg). ^p < 0.05, TBI + VEH vs. TBI + GAL (0.5, 2.0., and 5.0 mg/kg). n = 10–18/group.