FIG. 4.
Mean (±SEM) cortical lesion volume (mm3) at 4 weeks post-TBI. (A) There were no statistical differences (p > 0.05) in lesion volumes among groups suggesting that galantamine (GAL) did not attenuate TBI-induced cortical tissue loss regardless of dose, relative to vehicle (VEH). (B) Bright field image (stitched) (10×) of Cresyl violet-stained representative coronal sections (7-μm thick, Bregma ∼ −1.20 mm). Upper left = TBI + VEH; Upper right = TBI + GAL (0.5 mg/kg); Bottom left = TBI + GAL (2.0 mg/kg); Bottom right = TBI + GAL (5.0 mg/kg). n = 8–11/group.