Table 2.

Comparison of Traditional Hepatic Dysfunction Biomarkers in S-HD and S-CON Patients Throughout ICU Stay

Hepatic Test	S-HD	S-CON	P value
Bilirubin
Day-1	22.0 (13.0–31.0)	4.0 (3.0–6.0)	< 0.001
Day-3	15.0 (11.0–45.0)	5.0 (3.0–7.0)	< 0.001
Day-5	15.0 (8.8–54.5)	5.0 (3.0–6.0)	< 0.001
Day-7	15.0 (11.0–55.0)	6.0 (4.0–7.0)	< 0.001
Albumin
Day-1	27.0 (21.7–36.0)	32.5 (29.0–38.0)	0.033
Day-3	30.0 (22.8–34.3)	33.0 (27.0–37.0)	0.695
Day-5	31.0 (21.0–37.0)	35.0 (31.3–38.8)	0.042
Day-7	31.0 (24.0–33.0)	32.0 (27.0–37.0)	0.274
ALT
Day-1	60.0 (20.0–142.0)	17.5 (12.3–33.3)	< 0.001
Day-3	52.0 (21.0–156.0)	22.0 (16.0–33.0)	0.007
Day-5	46.0 (30.3–146.3)	27.5 (13.8–68.3)	0.071
Day-7	50.0 (24.0–100.0)	51.0 (19.0–114.0)	0.948
AST
Day-1	94.0 (47.0–198.0)	30.5 (18.5–58.5)	< 0.001
Day-3	62.0 (37.0–222.0)	34.0 (25.0–48.0)	< 0.001
Day-5	81.0 (39.0–214.3)	28.0 (23.3–60.5)	0.004
Day-7	78.0 (36.0–105.0)	32.0 (22.0–80.0)	0.089
GGT
Day-1	49.0 (25.0–74.0)	20.5 (11.5–49.5)	0.001
Day-3	74.0 (43.0–150.0)	24.0 (12.0–52.0)	< 0.001
Day-5	108.5 (69.5–172.8)	30.5 (18.0–62.3)	< 0.001
Day-7	94.0 (52.0–220.0)	58.0 (17.0–108.0)	0.071

Data is presented as median (IQR). P < 0.05 values bolded (Mann–Whitney U test)

Bilirubin is measured in μmol/L, albumin g/L, ALT, AST and GGT in U/L