Table 3.
Comparison of Putative Hepatic Dysfunction Biomarkers in S-HD and S-CON Patients Throughout ICU Stay
| Hepatic Test | S-HD | S-CON | P value |
|---|---|---|---|
| ARG1 | |||
| Day-1 | 1346.0 (387.7–5922.0) | 343.0 (309.5–1656.0) | 0.047 |
| Day-3 | 638.9 (304.0–1799.0) | 338.0 (184.0–768.2) | 0.191 |
| Day-5 | 1052.0 (328.4–3353.0) | 343.0 (304.0–1086.0) | 0.179 |
| Day-7 | 781.1 (328.8–1949.0) | 860.0 (349.5–1915.0) | 0.419 |
| MDH1 | |||
| Day-1 | 325.0 (315.0–355.0) | 325.0 (315.0–355.0) | 0.886 |
| Day-3 | 325.0 (315.0–350.5) | 325.0 (325.0–355.0) | 0.480 |
| Day-5 | 325.0 (315.0–355.0) | 325.0 (320.0–355.0) | 0.837 |
| Day-7 | 346.0 (322.5–355.0) | 325.0 (325.0–355.0) | 0.431 |
| GSTα | |||
| Day-1 | 3795.0 (913.4–35,195.0) | 1444.0 (926.3–2684.0) | 0.039 |
| Day-3 | 3494.0 (920.0–8711.0) | 1439.0 (634.1–1439.0) | 0.093 |
| Day-5 | 2329.0 (1320.0–9719.0) | 1729.0 (818.6–7023.0) | 0.527 |
| Day-7 | 1370.0 (553.8–2267.0) | 2843.0 (1572.0–6246.0) | 0.013 |
| 5-NT | |||
| Day-1 | 4161.0 (2642.0–6299.0) | 2769.0 (1596.0–4200.0) | 0.006 |
| Day-3 | 4055.0 (2074.0–7825.0) | 3023.0 (1403.0–4099.0) | 0.009 |
| Day-5 | 3843.0 (2260.0–4942.0) | 1692.0 (1017.0–4518.0) | 0.051 |
| Day-7 | 3733.0 (1456.0–7502.0) | 1447.0 (1110.0–4107.0) | 0.079 |
| SDH | |||
| Day-1 | 33,567.0 (15,480.0–169093.0) | 6645.0 (1625.0–24448.0) | 0.014 |
| Day-3 | 17,052.0 (3972.0–110293.0) | 9758.0 (1940.0–38457.0) | 0.317 |
| Day-5 | 52,233.0 (14,114.0–101592.0) | 18,321.0 (6131.0–61893.0) | 0.294 |
| Day-7 | 32,005.0 (5584.0–72385.0) | 43,917.0 (11,802.0–102244.0) | 0.316 |
Data is presented as median (IQR). P < 0.05 values bolded (Mann–Whitney U test)
Biomarkers are measured in pg/mL