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. 2025 Jan 3;16:362. doi: 10.1038/s41467-024-55431-3

Fig. 3. The rearrangement RING domain in different complexes.

Fig. 3

a Superposition of the map and model of the LGR4-RSPO2-ZNRF3(RING) (1:1:1, heterotrimer, contour level: 2.8σ). b Map of the LGR4-RSPO2-ZNRF3(RING) (1:2:2, pentamer B, contour level: 2.8σ). c Superposition of the map and model of the TM helix and RING domain in pentamer B, shown in the low-pass map (contour level: 4.38σ) from different perspectives. d Map of ZNRF3(RING) in pentamer B (contour level: 5.4σ). e Wnt3a-stimulated-TOPFlash activity regulated by WT or V229-P-S230 mutant of ZNRF3, n = 4, p value = 0.0356. Source data are provided as a Source Data file. f Map of ZNRF3 (ΔRING) in di-heterotrimer (contour level: 11.08σ). g The map of the LGR4-RSPO2-ZNRF3 complex in its di-heterodimer form (2:2:2), with ZNRF3 containing the RING domain. Each value represents the mean ± SEM from four independent experiments.