Table 2.
Associations between selected serum aldehydes exposure and level of SUA.
| Aldehydes | Log-transformed |
T1 |
T2 |
T3 |
Ptrend | Adjusted Ptrenda | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| β (95%CI) | P value | Adjusted P valuea | β (95%CI) | β (95%CI) | P value | β (95%CI) | P value | |||
| Benzaldehyde | ||||||||||
| Model 1 | −0.111 (−0.225, 0.003) | 0.075 | 1.000[Ref.] | −0.165 (−0.382, 0.053) | 0.159 | −0.268 (−0.485, −0.051) | 0.028 | 0.028 | ||
| Model 2 | −0.006 (−0.115, 0.102) | 0.911 | 1.000[Ref.] | −0.066 (−0.230, 0.098) | 0.442 | −0.096 (−0.290, 0.098) | 0.349 | 0.347 | ||
| Model 3 | 0.005 (−0.089, 0.099) | 0.924 | 0.944 | 1.000[Ref.] | 0.001 (−0.160, 0.161) | 0.994 | −0.031 (−0.211, 0.149) | 0.739 | 0.739 | 0.739 |
| Isopentanaldehyde | ||||||||||
| Model 1 | 0.025 (−0.112, 0.162) | 0.729 | 1.000[Ref.] | 0.237 (0.060, 0.414) | 0.019 | 0.154 (−0.046, 0.354) | 0.151 | 0.157 | ||
| Model 2 | −0.061 (−0.157, 0.035) | 0.233 | 1.000[Ref.] | 0.141 (−0.028, 0.310) | 0.123 | 0.021 (−0.105, 0.148) | 0.744 | 0.762 | ||
| Model 3 | 0.004 (−0.102, 0.109) | 0.944 | 0.944 | 1.000[Ref.] | 0.145 (−0.002, 0.293) | 0.065 | 0.086 (−0.098, 0.270) | 0.375 | 0.271 | 0.325 |
| Propanaldehyde | ||||||||||
| Model 1 | 0.313 (0.050, 0.577) | 0.034 | 1.000[Ref.] | 0.189 (0.006, 0.371) | 0.061 | 0.242 (0.017, 0.467) | 0.053 | 0.231 | ||
| Model 2 | 0.230 (0.028, 0.432) | 0.042 | 1.000[Ref.] | 0.097 (−0.062, 0.255) | 0.251 | 0.170 (−0.030, 0.370) | 0.117 | 0.702 | ||
| Model 3 | 0.263 (0.062, 0.464) | 0.022 | 0.044 | 1.000[Ref.] | 0.139 (−0.035, 0.312) | 0.138 | 0.214 (0.032, 0.397) | 0.036 | 0.214 | 0.321 |
| Butyraldehyde | ||||||||||
| Model 1 | 0.347 (0.194, 0.499) | <0.001 | 1.000[Ref.] | −0.003 (−0.226, 0.220) | 0.979 | 0.428 (0.270, 0.586) | <0.001 | <0.001 | ||
| Model 2 | 0.269 (0.134, 0.404) | 0.001 | 1.000[Ref.] | −0.005 (−0.219, 0.210) | 0.965 | 0.351 (0.205, 0.497) | <0.001 | <0.001 | ||
| Model 3 | 0.317 (0.173, 0.460) | 0.001 | 0.003 | 1.000[Ref.] | 0.046 (−0.102, 0.195) | 0.550 | 0.446 (0.299, 0.593) | <0.001 | <0.001 | <0.001 |
| Hexanaldehyde | ||||||||||
| Model 1 | 0.340 (0.100, 0.580) | 0.014 | 1.000[Ref.] | 0.072 (−0.056, 0.199) | 0.287 | 0.392 (0.124, 0.660) | 0.012 | 0.011 | ||
| Model 2 | 0.391 (0.206, 0.575) | 0.001 | 1.000[Ref.] | 0.182 (0.065, 0.298) | 0.008 | 0.458 (0.233, 0.684) | 0.001 | 0.001 | ||
| Model 3 | 0.360 (0.201, 0.518) | <0.001 | <0.001 | 1.000[Ref.] | 0.228 (0.044, 0.411) | 0.028 | 0.428 (0.216, 0.640) | 0.001 | 0.001 | 0.003 |
| Heptanaldehyde | ||||||||||
| Model 1 | 0.253 (0.067, 0.439) | 0.018 | 1.000[Ref.] | 0.057 (−0.211, 0.325) | 0.683 | 0.319 (0.140, 0.497) | 0.003 | 0.004 | ||
| Model 2 | 0.235 (−0.011, 0.482) | 0.081 | 1.000[Ref.] | 0.078 (−0.191, 0.347) | 0.578 | 0.242 (0.028, 0.456) | 0.043 | 0.043 | ||
| Model 3 | 0.195 (−0.008, 0.398) | 0.079 | 0.119 | 1.000[Ref.] | 0.079 (−0.140, 0.297) | 0.492 | 0.213 (0.051, 0.374) | 0.021 | 0.022 | 0.044 |
SUA: serum uric acid; OR: odds ratio; 95%CI: 95 % confidence interval; FRD: false discovery rate.
Model 1 was a crude model, model 2 was adjusted for age, sex and race, and model 3 was further adjusted for educational level, family poverty income ratio group, body mass index, smoking status, drinking status, hypertension, diabetes, hypercholesterolemia, and chronic kidney disease.
Serum aldehydes exposure was analyzed as both continuous and categorical variables. The categorical variables were grouped by tertiles, with T1, T2 and T3 representing the first, second and third tertiles, respectively.
a
P value was adjusted by FDR method.