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. 2025 Jan 3;74(2):67. doi: 10.1007/s00262-024-03921-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — Correlation between TDO2 expression and CD8 + T cell infiltration in cSCC patients. A-D Immunohistochemical analysis of the correlation between TDO2 + cells and CD4 + T cells, CD8 + T cells, FOXP3 + cells, and CD206 + cells. The figure displays scatter plots and regression analysis demonstrating the correlation between the quantity of TDO2 + cells and the numbers of CD4 + T cells, CD8 + T cells, FOXP3 + cells, and CD206 + cells. The linear regression equation and P-value adjacent to the scatter plots indicate a significant negative correlation between the number of TDO2 + cells and CD8 + T cells, while the correlation with other immune cell markers is not significant. Scale bar = 100 µm. E Representative mIHC images of TDO2 + cells and CD8 + T cells. The image shows the expression of TDO2 (green) and CD8 (orange) via immunofluorescence staining in cSCC patient tissue samples. The left image represents an area of high TDO2 expression, while the right image represents an area of low TDO2 expression. DAPI (blue) is used for nuclear staining. Scale bar = 50 µm. Statistical significance is indicated as *p < 0.05