Fig. 2.

Epitopes fusion with FcRn could lead to greater T cell response after immunization. Mice were allocated into three groups and immunized twice with mRNA-LNPs encoding Fluc (luciferase), Fluc-FcRn, and mTubulin (tubulin from Mus musculus). The specific T cell responses were then assessed using ELISPOT. A Schematic of the immunization schedule with mRNA-LNPs. B Splenocytes were stimulated with single peptides from luciferase. C Statistical analysis of the spot counts. Data are shown as mean values ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001