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Safety profiles. A The cytotoxicity of the four mRNA-LNPs used in the study was detected using CCK-8 kit. B AST and ALT activities in peripheral blood were measured in tumor-bearing mice treated with PBS, mTubulin mRNA-LNP, and vaccine. C AST and ALT activities in peripheral blood were evaluated in mice immunized with PBS, mTubulin mRNA-LNP, and vaccine. Data are shown as mean values ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001
