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. 2025 Jan 3;16:364. doi: 10.1038/s41467-024-55744-3

Fig. 7. Applications in the synthesis of chiral ligands and natural products.

Fig. 7

A One-pot enantioselective synthesis of optically pure 1,2-diol and 1,3-diol form ethylene glycol and 1,3-propanediol. B One-pot diastereoselective synthesis of 1,2-diol bearing two stereogenic centers. C Gram-scale preparation of optically pure 1,2-diol 3co and 1,3-diol 5aa. D Asymmetric synthesis of (-)-Epinephrine. E Asymmetric synthesis of (R)-Carisbamate. F Formal synthesis of Pradefovir. G Formal synthesis of Solabegron. H Formal synthesis of Aprepitant. I Concise and asymmetric synthesis of natural phenylpropanoid and chiral ligand PydiPhos. J Formal synthesis of (S,S)-(+)-Reboxetine. K Formal synthesis of (-)-Bursatellin and Preoxazinin. n-BuLi butyl lithium, PTSA p-toluene sulfonic acid, DMP 2,2-dimethoxypropane, Phth phthalimide, CDI 1,1′-carbonyldiimidazole, TsCl 4-toluenesulfonyl chloride, TFA trifluoroacetic acid.