Table 4.
Single nucleotide polymorhisms associated with horse weight and size annotated using VEP and DAVID tools.
| Variant ID | Location | Gene |
P-value |
GO term – biological process | |
|---|---|---|---|---|---|
| Size | Weight | ||||
| BIEC2_316765 | 15:68252917 | ALK | – | 0.0008545 | GO:0006468∼protein phosphorylation |
| AX-103265166 | 2:55284182 | BNIP3L | 2.3 × 10−5 | 1.80 × 10−5 | GO:0016239∼positive regulation of macroautophagy |
| AX-104903715 | 4:93924679 | BRAF | 0.0007523 | 0.0004619 | GO:0000165∼MAPK cascade |
| BIEC2_946110 | 6:29507974 | CACNA1C | 0.0002397 | – | GO:0002520∼immune system development |
| BIEC2_140284 | 11:13962473 | CACNG4 | – | 3.181 × 10−5 | GO:0019226∼transmission of nerve impulse |
| Affx-102683437 | 4:79003820 | CADPS2 | – | 0.0001952 | GO:0006887∼exocytosis |
| AX-104609861 | 6:85773796 | CCT2 | – | 0.0007669 | GO:0006457∼protein folding |
| BIEC2_508762 | 2:116459352 | CFI | – | 0.0004362 | GO:0006508∼proteolysis |
| BIEC2_508766 | 2:116465026 | CFI | 0.0002012 | 0.0001068 | GO:0006508∼proteolysis |
| BIEC2_508769 | 2:116466442 | CFI | 0.0001972 | 0.0001277 | GO:0006508∼proteolysis |
| TBIEC2_331745 | 15:68417648 | CLIP4 | – | 0.0002872 | GO:0031122∼cytoplasmic microtubule organization |
| Affx-101130275 | 4:60087882 | CPVL | 0.0009387 | – | GO:0006508∼proteolysis |
| BIEC2_700308 | 27:2259858 | CSGALNACT1 | – | 0.0004961 | GO:0001958∼endochondral ossification |
| BIEC2_725599 | 28:5564261 | CSRP2 | 0.0003285 | – | GO:0045214∼sarcomere organization |
| AX-103706694 | 1:120490380 | CYP11A1 | 1 × 10−6 | 1.00 × 10−7 | GO:0006700∼C21-steroid hormone biosynthetic process |
| TBIEC2_498975 | 2:40275747 | DISP3 | 0.0004661 | – | GO:0045665∼negative regulation of neuron differentiation |
| AX-103721396 | 7:63690864 | DLG2 | 0.0008281 | 1.00 × 10−7 | GO:0007268∼chemical synaptic transmission |
| BIEC2_1004624 | 7:62981215 | DLG2 | 0.0009895 | – | GO:0007268∼chemical synaptic transmission |
| BIEC2_722382 | 27:39199656 | DLGAP2 | – | 0.0002175 | GO:0023052∼signaling |
| AX-103583267 | 26:37333692 | DSCAM | – | 0.0004288 | GO:0007156∼homophilic cell adhesion via plasma membrane adhesion molecules |
| Affx-103045508 | 2:27182213 | EPB41 | 0.0008206 | – | GO:0007049∼cell cycle |
| TBIEC2_889720 | 4:8502727 | EPDR1 | – | 0.0004253 | GO:0007160∼cell-matrix adhesion |
| BIEC2_852365 | 3:115596394 | EVC | 0.0009599 | – | GO:0003416∼endochondral bone growth |
| BIEC2_416905 | 18:63653165 | FAM171B | – | 0.0009746 | GO:0001525∼angiogenesis |
| Affx-102845142 | 28:31765971 | FBXO7 | 0.0003695 | 0.0001627 | GO:0000422∼mitophagy |
| BIEC2-472336 | 2:37787520 | FHAD1 | 0.0003518 | −0.0004809 | – |
| BIEC2_14481 | 1:32086433 | FRAT1 | 5.366 × 10−5 | 0.0006401 | GO:0090263∼positive regulation of canonical Wnt signaling pathway |
| Affx-102013817 | 17:62060245 | GPC5 | – | 0.0004061 | GO:0016477∼cell migration |
| Affx-102676537 | 6:24907627 | HDAC4 | 1.5 × 10−5 | 3.00 × 10-7 | GO:0000122∼negative regulation of transcription from RNA polymerase II promoter |
| BIEC2_14318 | 1:30611785 | HPSE2 | – | 0.0002113 | GO:0008283∼cell proliferation |
| ITGA2B_19245752_GT | 11:19245752 | ITGA2B | 1 × 10−6 | – | GO:0001525∼angiogenesis |
| KIT_79540741_W16 | 3:79540741 | KIT | 1 × 10−6 | 1.00 × 10−7 | GO:0001541∼ovarian follicle development |
| KIT_79580000_W7 | 3:79580000 | KIT | 1 × 10−6 | 1.00 × 10−7 | GO:0001541∼ovarian follicle development |
| BIEC2_320442 | 15:75799411 | LDAH | 0.0003885 | – | GO:0019915∼lipid storage |
| Affx-101492057 | 10:19641430 | NOSIP | 6 × 10−6 | 1.00 × 10−7 | – |
| AX-104335949 | 5:40161837 | NUP210L | 1 × 10−6 | 1.00 × 10−7 | – |
| PAX3_11199140_SW4 | 6:11199140 | PAX3 | 1 × 10−6 | 1.00 × 10−7 | GO:0006355∼regulation of transcription |
| AX-104963491 | 12:30951642 | PITPNM1 | 2 × 10−6 | 1 × 10−7 | GO:0015914∼phospholipid transport |
| BIEC2_887173 | 5:2222786 | PM20D1 | 0.0002478 | – | GO:0006520∼cellular amino acid metabolic process |
| BIEC2_783022 | 3:57169047 | PRKG2 | – | 0.0007432 | GO:0006468∼protein phosphorylation |
| BIEC2_783026 | 3:57171222 | PRKG2 | – | 0.0003162 | GO:0006468∼protein phosphorylation |
| BIEC2_885537 | 4:107978404 | PTPRN2 | – | 0.0009618 | GO:0006470∼protein dephosphorylation |
| BIEC2_591905 | 22:33100482 | PTPRT | 0.0006552 | – | GO:0006470∼protein dephosphorylation |
| Affx-103079316 | 12:30867790 | RAD9A | – | 3.127 × 10−5 | GO:0000076∼DNA replication checkpoint |
| AX-104886193 | 25:31276468 | RALGPS1 | 0.0001003 | 8.00 × 10−7 | GO:0007264∼small GTPase mediated signal transduction |
| Affx-102836572 | 17:50354202 | SLAIN1 | 0.0004986 | 1.00 × 10−6 | GO:0007020∼microtubule nucleation |
| SLC36A1_25884457_Champagne | 14:25884457 | SLC36A1 | 1 × 10−6 | 1.00 × 10−7 | GO:0015808∼L-alanine transport |
| BIEC2_11418 | 1:24106986 | SORCS1 | 0.0006665 | – | GO:0006892∼post-Golgi vesicle-mediated transport |
| BIEC2_954544 | 6:50669754 | SOX5 | – | 0.0009407 | GO:0006357∼regulation of transcription from RNA polymerase II promoter |
| BIEC2_1011868 | 7:87211576 | SOX6 | 0.0006732 | – | GO:0006357∼regulation of transcription from RNA polymerase II promoter |
| AX-104226721 | 9:36874369 | SPIDR | 1 × 10p | 4.00 × 10−7 | GO:0000724∼double-strand break repair via homologous recombination |
| AX-104855978 | 28:39009737 | TEF | 0.0007493 | – | GO:0006357∼regulation of transcription from RNA polymerase II promoter |
| BIEC2_486399 | 2:69215803 | TLL1 | – | 0.0006598 | GO:0006508∼proteolysis |
| BIEC2_1004550 | 7:62165511 | TMEM126B | – | 0.0004348 | GO:0032094∼response to food |
| BIEC2_195234 | 12:24939247 | TMEM138 | – | 6 × 10−7 | – |
| AX-103728731 | 9:84365361 | ZC3H3 | 0.0005481 | 2.00 × 10−6 | – |
| Affx-101705964 | 10:25531136 | ZNF787 | 0.0002468 | – | GO:0000122∼negative regulation of transcription from RNA polymerase II promoter |