Correction: J Exp Clin Cancer Res42, 219 (2023)
10.1186/s13046-023-02788-w
Following the publication of the original article [1], the authors identified an error in Fig. 7D. The image presented for the MKRN1 f/f group (IHC staining of TGF-β1) was inadvertently incorrect due to an oversight during figure preparation.
Fig. 7.
MKRN1 promotes tumour proliferation and metastasis in vivo. A Comparative graph showing the number of intestinal lesions in the MKRN1 [+/+] and MKRN1 [f/f ] groups. B Haematoxylin–eosin (H&E) staining of the intestine of both groups of mice (scale bar: 100 μm). C H&E staining of the liver in the two groups of mice (scale bar: 100 μm; scale bar: 20 μm). D IHC staining for Ecadherin, MKRN1, SNIP1, and TGFβ1 in the intestinal tissues of the two groups of mice (scale bar: 100 μm). E Western blotting analysis of Ecadherin, MKRN1, SNIP1, and TGFβ1 protein expression in intestinal tissues of the two groups of mice. F MKRN1 facilitates the TGFβ signalling via ubiquitination and degradation of SNIP1, thereby promoting EMT in CRC cells. *P < 0.05, *P < 0.01, * P < 0.001
The correct figure is presented below:
Correct Fig. 7D
Fig. 7.
MKRN1 promotes tumour proliferation and metastasis in vivo. A Comparative graph showing the number of intestinal lesions in the MKRN1 [+/+] and MKRN1 [f/f ] groups. B Haematoxylin–eosin (H&E) staining of the intestine of both groups of mice (scale bar: 100 μm). C H&E staining of the liver in the two groups of mice (scale bar: 100 μm; scale bar: 20 μm). D IHC staining for Ecadherin, MKRN1, SNIP1, and TGFβ1 in the intestinal tissues of the two groups of mice (scale bar: 100 μm). E Western blotting analysis of Ecadherin, MKRN1, SNIP1, and TGFβ1 protein expression in intestinal tissues of the two groups of mice. F MKRN1 facilitates the TGFβ signalling via ubiquitination and degradation of SNIP1, thereby promoting EMT in CRC cells. *P < 0.05, *P < 0.01, * P < 0.001
Incorrect Fig. 7D
The correction does not compromise the validity of the conclusions and the overall content of the article. The original article [1] has been updated.
Footnotes
The online version of the original article can be found at 10.1186/s13046-023-02788-w.
Publisher’s note
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Yi Zhang, Qin-shan Li and Hong-lin Liu contributed equally to this work.
Contributor Information
Qin-shan Li, Email: liqinshan@gmc.edu.cn.
Li-hong Liu, Email: llh-hong@outlook.com.
Meng-xing Li, Email: lmx1234@gmc.edu.cn.
References
- 1.Zhang Y, Li Q, Liu H, et al. MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation. J Exp Clin Cancer Res. 2023;42:219. 10.1186/s13046-023-02788-w. [DOI] [PMC free article] [PubMed] [Google Scholar]