Fig. 2.

Motor and cognitive performance of 10-month-old homozygous ANXA11-P36R knock-in mice. a Motor decline in homozygous (R/R) mutant mice compared with wild-type (+ / +). Mutant mice showed reduced grip strength (p = 0.0466), shorter hanging endurance time (p = 0.0078), and decreased retention time on the rotarod test (p = 0.0329) compared with wild-type. b Representative heatmap and results from the open field test with no significant difference between the two groups. c The results from the elevated plus maze. Homozygous ANXA11-P36R knock-in mice displayed tendency of anxiety-like behavior with no significance compared with wild-type (p = 0.052). d Dementia was not evident in homozygous 10-month-old mutant mice. The percentage of time spent investigating a novel object (left, NOR), and the number of entries into the novel arm and spontaneous alternation (right, Y maze) showed no significant differences between wild-type and mutant mice. Data are presented as mean ± SEM (n = 8 mice per group), with statistical analysis performed using Student’s unpaired t-test