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MTOR activation in homozygous ANXA11-P36R knock-in mice. In the cortex of 2-month-, 4 month- and 9-month-old mutant mice, mTOR pathway was activated indicated by elevated p-mTOR/mTOR, p-AKT/AKT, and p-P70S6K/P70S6K levels. Representative immunoblots illustrate these alterations, with data presented as mean ± SEM (n = 4 biologically independent replicates per group). One-way ANOVA was used to determine statistical significance. *p < 0.05, **p < 0.01, ***p < 0.001
