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Transcriptome-wide association study (TWAS) for AD neuropathological features. The x-axis of Manhattan plot represents the genomic position of the corresponding gene, and the y-axis of Manhattan plot represents -log10-transformed association combined P-value using ACAT. Each dot represents the association for one specific gene. The line shows combined P value 9.71 × 10–6. A TWAS for neuropathologically confirmed AD case–control sample. B TWAS for Braak stage. C TWAS for NP scor
