Fig. 5.

Course of 36-Item Short-Form Survey physical functioning domain (SF-36 PF) over the study period in patients who received a second cycle of IA therapy (n = 7). The duration of IA therapy is indicated by the green bar. Error bars represent 95% confidence intervals. Data were analyzed using a linear mixed-effects model fitted by restricted maximum likelihood (REML) for each cycle, with t-tests computed using Satterthwaite's method for degrees of freedom with significance levels indicated as ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.