Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2025 Jan 4;16:388. doi: 10.1038/s41467-024-55581-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

PMC Copyright notice

Fig. 4 — a Enrichment analysis of Gene Ontology (GO) terms for 96 HR-related genes against the whole genome background. GO terms are categorized into three distinct domains, represented as vertical stacked bars and highlighted in the shaded area. Regulatory function-related GO terms are highlighted in bold text. The blue bar chart represents the observed count of HR-related genes in corresponding GO terms (noting that each gene can correspond to multiple GO terms). The false discovery rate (FDR) for significantly enriched GO terms (FDR < 0.05) are labeled in the rightmost. Source data are provided as a Source Data file. b STRING association analysis for 96 HR-related genes. Only node interactions with a confidence score greater than 0.7 are displayed, while disconnected nodes in the network are hidden and nodes connected solely through physical interactions were removed manually. Nodes are color-coded according to four clustered groups with possible epistatic signals, while connecting lines are colored based on the evidence supporting the interaction within the STRING database. Bold gene names with asterisks indicate regulatory proteins, and the red text in parentheses below the gene name indicates the HR associated with the corresponding gene.