Table 3.
Patent table of luteolin related products.
| Application type | Product name | Essential component | Manufacturing enterprise | Function | Website |
|---|---|---|---|---|---|
| Medicine field | Compositions for the treatment of viral infections | Luteolin, quercetin, kaempferol, vitamin C | Hofleitner, Peter[Us/Us] | Prevention or treatment of viral infection | https://patentscope2.wipo.int/search/en/detail.jsf?docId=WO2021257252 |
| Medicine field | Compositions containing antioxidants for the treatment of pain and inflammation | Oleuropein, hydroxytyrosol (3 ′ 4 ' -DHPEA) and tyrosol (p-DHPEA) and flavonoids (rutin, quercetin, luteolin and apigenin). | Atlas Olive Oils Sarl.[Ma/Ma] | In vitro inhibition of PGE2, LTB4, TNF-a, IL-6, IL-1 and high-sensitivity c-reactive protein (hs-CRP). | https://patentscope2.wipo.int/search/en/detail.jsf?docId=WO2020095236 |
| Medicine field | Use of luteolin in preparation of medicament for preventing and treating dengue virus infection | Luteolin | Dongguan Mathematical Engineering Academy Of Chinese Medicine, Guanzhou University Of Chinese Medicine[Cn/Cn] | Anti-dengue fever virus, prevention and treatment of dengue fever infection | https://patentscope2.wipo.int/search/en/detail.jsf?docId=WO2018107614 |
| Medicine field | Composition containing active components of dracocephalum moldavica L. Against myocardial ischemia-reperfusion injury | Luteolin, kaempferol and luteolin-7-0 glucoside | Nanjing Road Yinglunze Biopharmaceutical Technology Co., Ltd.,Nanjing, Jiangsu (CN) | Reduce hypoxia/reoxygenation-induced rat primary myocardial cell injury and apoptosis rate; reduce cell LDH leakage; improve cell glycolysis, improve cell energy metabolism disorders | https://patentscope2.wipo.int/search/en/detail.jsf?docId=US204140502 |
| drugs & medical technology | Use of luteolin-7-diglucuronide in preparation of drug for preventing cardiac damage or fibrosis | Luteolin-7-diglucuronide | Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences | Inhibition of myocardial cell necrosis, granulation tissue formation, inflammatory cell invasion, myocardial fibrosis formation | https://patentscope2.wipo.int/search/en/detail.jsf?docId=WO2017148338 |
| Nanomedicine and pharmaceutical nanotechnology | Development of nanomaterial for controlled release of luteolin in the treatment of neurodegenerative diseases | Luteolin-p (HEMA-MATrp) nanopolymer | EGE Universltesi[TR/TR] | Increasing oral bioavailability, increasing plasma half-life, reducing dose requirements and intake frequency play a neuroprotective and neuroregulatory role in neurodegeneration. | https://patentscope2.wipo.int/search/en/detail.jsf?docId=WO2022139732 |
| The field of nutritional supplements | Nutraceutical composition for pde4 inhibition, enhanced dopamine metabolism and long term potentiation | Luteolin, quercetin, hesperidin, oleanthin A, luteolin, xanthone or resveratrol and cyclic adenosine monophosphate (cAMP) enhancer. | Justin Sher, San Mateo, CA(US) | Increase cognitive function | https://patentscope2.wipo.int/search/en/detail.jsf?docId=US294690857 |
| Drugs, health products | composition for preventing or treating attention deficit hyperactivity disorder comprising luteolin | Luteolin, artichoke extract or part thereof | Fuqing University Industry-University Cooperation Group, Quanbei University Industry-University Cooperation Group | It has antagonist effect on dopamine Da receptor (DR). | https://patentscope2.wipo.int/search/en/detail.jsf?docId=KR335127762 |
| Pharmaceuticals, health functional foods | composition for preventing or treating arthritis and autoimmune diseases comprising luteolin 7-o-(6 prime; -malonylglucoside) derived from leaf of anthriscus sylvestris as active component | Luteolin 7-0- (6 ' -malonylglucoside) | Korea University Industry-University Cooperation Group | Inhibition of NF-KB nuclear translocation; inhibition of MMP-3 or MMP-13 production; for the prevention or treatment of arthritis | https://patentscope2.wipo.int/search/en/detail.jsf?docId=KR248945790 |
| Pharmaceuticals, health food | pharmaceutical composition for preventing or treating liver disease containing luteolin as active component | luteolin | Daegu Korean Medical University Industry-University Cooperation Group | Inhibition of hepatocyte CHOP protein expression; inhibit the activity of endoplasmic reticulum stress in hepatocytes | https://patentscope2.wipo.int/search/en/detail.jsf?docId=KR237670820 |
| Pharmaceutical composition or health care composition | composition for inhibiting skin cell proliferation and/or anti-inflammation method for inhibiting skin cell proliferation and/or anti-inflammation and method for treating skin diseases and/or inflammatory diseases | Apigenin, luteolin | Industrial Technology Research Institute, Hsinchu(TW) | Inhibit skin cell proliferation and/or anti-inflammation | https://patentscope2.wipo.int/search/en/detail.jsf?docId=US313640107 |
| Pharmaceutical products, functional foods | pharmaceutical composition for preventing or treating endometriosis comprising quercetin, luteolin, delphinidin or mixture thereof | Quercetin, luteolin, delphinidin or their mixture | Koryo University Industry-University Cooperation Group | Inhibit the phosphorylation of lower signal transduction substances in PI3K/AKT signaling pathway; inhibition of endometriosis cell proliferation; prevention and treatment of endometriosis | https://patentscope2.wipo.int/search/en/detail.jsf?docId=KR323639814 |
| Pharmaceuticals, health products, functional foods | use of luteolin and derivatives thereof in the prevention and treatment of heart failure | Luteolin or its derivatives | The University Of Tokyo, Jp; Theravalues Corporation, Jp |
Inhibition of cardiac fibrosis, ventricular wall thickening, large heart, heart failure and aneurysm, prevention and treatment of heart disease. | https://patentscope2.wipo.int/search/en/detail.jsf?docId=CA96757129 |
| Health functional food field | composition for preventing or treating diabetes | More than two compounds composed of glyceollin, luteolin, genistein and Daidzein. | Qingbei University Industry-University Cooperation Group | Inhibit α-glucosidase activity, prevent or improve diabetes | https://patentscope2.wipo.int/search/en/detail.jsf?docId=KR332966388 |
| Cosmetics, pharmaceutical field | antipruritic composition containing mixture of luteolin and apigenin as active ingredient | Luteolin, apigenin | Atq & A Technology Co., LTD | Inhibit the production of IL-31 and IL33 in vivo, prevent or improve pruritus. | https://patentscope2.wipo.int/search/en/detail.jsf?docId=KR339300676 |
| Cosmetics, drugs, food | composition for skin whitening containing ruteolin-7-sulfate as active ingredient | Luteolin-7-sulfate | Qingbei University Industry-University Cooperation Group | Inhibition of tyrosinase activity, inhibition of melanin production | https://patentscope2.wipo.int/search/en/detail.jsf?docId=KR203611707 |
| Pharmaceuticals, cosmetics, food | extracellular atp concentration inhibitor | Rosmarinic acid, luteolin glucan | Ichimarupharcos Co., Ltd.[Jp/Jp] | Inhibit the increase of extracellular ATP concentration and improve skin viscoelasticity. | https://patentscope2.wipo.int/search/en/detail.jsf?docId=JP311618549 |
| Medical products, pharmaceuticals, health functional food, cosmetics, animal feed | antibacterial composition for inhibiting antibiotic-resistant staphylococcus aureus containing luteolin | luteolin | Republic of Korea (Director of Rural Revitalization) | Inhibition of drug-resistant Staphylococcus aureus | https://patentscope2.wipo.int/search/en/detail.jsf?docId=KR200974894 |
| Food, cosmetics and pharmaceuticals | Composition containing luteolin and its manufacturing method | Water-dispersible powder compositions of luteolin and quinoa saponin | Petroeuroasia Co., Ltd. Shizuoka 411–0903(JP) |
Increased water solubility of luteolin | https://patentscope2.wipo.int/search/en/detail.jsf?docId=JP300867650 |
| Soil regulating material technology field | A soil conditioner which can reduce the sodium ion content in rhizosphere soil and improve the salt resistance of crops. | Quercetin, luteolin, naringenin | China agricultural university | Stimulate soil microbial activity, improve rhizosphere soil biological fertility, significantly reduce rhizosphere soil sodium ion content, reduce salt damage, and enhance crop salt resistance and increase yield. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN394457854 |
| Medical health technology field | Application of luteolin in the preparation of drugs for the treatment or prevention of psoriasis | luteolin | Nanjing University (Suzhou) High-tech Research Institute | It is proved that luteolin exhibits good anti-inflammatory activity in the treatment of skin inflammation and can be used for anti-inflammatory treatment of psoriasis. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN383860716 |
| food field | An anti-allergic functional food based on egg albumin and luteolin and its application | Luteolin, egg white protein | Zhejiang Liziyuan Food Co., Ltd. | Using luteolin to form anti-allergic functional food | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN391948252 |
| Pharmaceutical preparation technology field | Luteolin green algae hydrogel preparation and its preparation method and application | Luteolin, green algae | Tibet university | It can be applied to dermatology, such as the treatment of diabetic refractory wounds, with high bioavailability; improving the storage stability of luteolin green algae hydrogel preparation | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN391138697 |
| Biological control technology field | A feeding inhibitor of soybean thrips and its screening method and application | Luteolin, coumaric acid, sinapic acid, phloridzin | China agricultural university | It is natural, green and safe, and the control effect on soybean thrips in the field can reach 82.6 %. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN376576852 |
| drugs & medical technology | Application of Luteolin in the Preparation of Atopic Dermatitis Lesions Treatment Drugs | Luteolin and its medicinal derivatives | Wuhan university | By inhibiting the increase of IL-4, IL-13, IL-6, TNF-α, IL-17, p-JAK2 and p-STAT3 levels to prevent, alleviate or treat atopic dermatitis lesions, it is more friendly to patients with spleen deficiency or poor thymus, and avoids the damage of glucocorticoid drugs to the spleen and thymus. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN379907896 |
| Emulsion preparation technology field | A Pickering emulsion stabilized by luteolin and its preparation method and application | Luteolin, deionized water, ethanol, specific edible oil | Dalian university of technology | The operation is simple, the light stability and viscosity of the prepared emulsion are improved, the retention rate of fat-soluble active substances is high, and the stability is good. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN382089055 |
| Emulsion preparation technology field | A fish skin gelatin emulsion stabilized by luteolin and its preparation method and application | Luteolin, ethanol, deionized water, corn oil, | Dalian university of technology | The emulsion prepared by the invention has small average particle size, uniform structure distribution, strong free radical scavenging ability and good stability, and can be used as an effective embedding system for fat-soluble active substances. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN380626173 |
| medicine field | The composition and application of luteolin and its derivatives as effective components to promote hair growth | Luteolin and its derivatives and preparation excipients | Zhejiang Xizhenglin Biotechnology Co., Ltd. | Promote hair growth in the hair removal area, increase growth rate and increase the number of hair follicles. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN376489988 |
| Drugs & medical technology | Application of luteolin combined with cichoric acid in the preparation of breast cancer therapeutic drugs | Luteolin, cichoric acid | China pharmaceutical university | It has a very good effect against triple negative breast cancer, and no side effects. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN376162969 |
| New drug use technology field | Application of a luteolin in the preparation of drugs for the treatment of gastric precancerous diseases | luteolin | Peking university third hospital | It significantly improved the state of gastric mucosal epithelial cells after bile acid intervention and down-regulated the expression of intestinal metaplasia-specific molecules CDX2 and KLF4. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN379067788 |
| Microneedle technology field | A luteolin soluble microneedle and its preparation method | luteolin | Zunyi medical university | Inhibit the expression of NLRP3 inflammasome in rheumatoid arthritis, reduce the expression of caspase-1, RANKL, VEGF and HIF-1α protein in toes, and break through the stratum corneum barrier of skin to effectively treat rheumatoid arthritis. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN377044029 |
| Food processing technology field | Simultaneous reduction of 4-methylimidazole and advanced glycation end products in baked foods based on natural active ingredients | Luteolin, rutin, naringenin | southern yangtze university | Reduce production costs and keep cake quality unaffected | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN371940248 |
| Biomedical technology field | A water celery composition for preventing toothache and its preparation method and application | Apigenin, luteolin, diosmetin, chlorogenic acid, caffeic acid and gallic acid | Chengdu Zhuxiang Biotechnology Co., Ltd. | Inhibition of Candida albicans, prevention and treatment of toothache | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN364708860 |
| medicine field | Application of luteolin in the preparation of drugs inhibiting the functional activity of Streptococcus pyogenes hemolysin | luteolin | Academy of Military Sciences, Chinese People 's Liberation Army | It can bind to SLO protein with high affinity to inhibit the functional activity of Streptococcus pyogenes hemolysin. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN362104413 |
| drugs & medical technology | A drug composition for the treatment of viral myocarditis and its preparation method | Luteolin, L-carnitine | Jiamusi university | Inhibit the inflammatory response of VMC myocardial tissue, reduce the apoptosis of myocardial tissue, and alleviate CVB3 virus-induced myocardial injury. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN360635831 |
| biosphere | An ES large biological fiber containing apigenin, luteolin and daidzein | Apigenin, luteolin, daidzein | Baicaobian Biotechnology (Qingdao) Co., Ltd. | It has excellent antibacterial properties, washing resistance and outstanding mechanical properties. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN364577449 |
| biotechnology field | Application of luteolin in the preparation of health care products or drugs to improve hypoxia tolerance | luteolin | Institute of Environmental Medicine and Occupational Medicine, Academy of Military Medical Sciences | It can significantly increase the activity of GSH-Px and T-SOD in serum, the activity of T-SOD in myocardial tissue and decrease the content of MDA in liver tissue under closed hypoxia. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN365364681 |
| Pharmaceutical cosmetics field | Application of luteolin and its pharmaceutically acceptable salts as dopamine receptor agonists in cosmetics | luteolin | Shanghai Chengmu Biotechnology Co., Ltd. | Activation of dopamine receptors, inhibition of adenylate cyclase activity and promotion of down-regulation of cyclic adenosine monophosphate | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN365362222 |
| biomedicine field | Targets of luteolin-autism related genes and their screening methods | luteolin | Air Force Medical University of Chinese PLA | Through 19 related disease targets such as TP53, AKT1, ERBB2, TNF, etc., we can regulate related inflammatory molecular signaling pathways. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN370573340 |
| drugs & medical technology | The use of luteolin in the preparation of drugs for the prevention and/or treatment of novel coronavirus infection | luteolin | Tianjin university of tcm | Inhibition of novel coronavirus S protein and ACE2 binding | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN351914442 |
| drugs & medical technology | Composition and its application in the preparation of drugs for the treatment of retinitis pigmentosa | Luteolin, Lycium barbarum glycopeptide | Aier Eye Hospital Group Co., Ltd. ; jinan University; ningxia Tianren Wolfberry Biotechnology Co., Ltd. | Significantly improve the survival rate of retinal photoreceptor cells in RP model mice, significantly improve the visual behavior of mice, and protect the retinal structure of RP model mice. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN342346824 |
| drugs & medical technology | New application of luteolin in enhancing the anti-Staphylococcus aureus effect of alkyl gallate compounds | luteolin | Taizhou university | Improve their inhibitory activity against Staphylococcus aureus, play a synergistic role | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN345642210 |
| Tumor drug research | Application of luteolin in the preparation of drugs targeting inhibition of ovarian cancer stem cells | luteolin | Chongqing University Affiliated Tumor Hospital | Inhibition of PPP2CA gene in Hippo/YPY pathway of ovarian cancer stem cells | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN341360642 |
| biomedicine | Application of luteolin in the preparation of drugs to increase the relative abundance of AKK bacteria in the intestine | luteolin | Shenzhen Xianhu Botanical Garden Management Office (Shenzhen Landscape Research Center) | Increase the relative abundance of AKK bacteria in the intestine and decrease the relative abundance of Firmicutes. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN353411664 |
| Disinfectant technology field | A medical antirust disinfectant and its preparation method | luteolin | Winnie Health (Shenzhen) Co., Ltd. | Improve the solubility of luteolin in aqueous solution and inhibit the oxidative corrosion of metals. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN334794875 |
| biomedicine | A drug composition for treating cerebral infarction and its application | Luteolin, kaempferol | Second Hospital of Hebei Medical University | Combined use can be prepared for the treatment of cardiovascular and cerebrovascular diseases, especially ischemic stroke. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318561439 |
| Pesticide technology field | A class of flavonoid metal complexes inhibiting citrus canker pathogen | Luteolin, metal (tin, chromium, copper, iron, zinc) | Nankai university | It has a significant bacteriostatic effect in vitro, and has the potential to develop as a new pesticide to inhibit plant bacterial diseases. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN320295248 |
| drugs & medical technology | Application of luteolin and its drug combinations | luteolin | Hong kong university of science and technology | Improve the function of nerve growth factor, promote the growth of cell protrusions, activate the promoter of neurofilament coding gene, promote the up-regulation of neurofilament expression, and activate tyrosine receptors and their downstream pathways. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN357955599 |
| Ophthalmic disease treatment technology field | Application of luteolin-7-O-glucoside in the preparation of drugs for the treatment of diseases caused by retinal degeneration | luteolin-7-o-glucoside | Hubei Ming Molybdenum Health Technology Co., Ltd. | Luteolin-7-O-glucoside can effectively treat retinopathy caused by retinal degeneration. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN311262777 |
| Fruit and vegetable preservation technology field | Application of luteolin in delaying postharvest quality deterioration of fruits | luteolin | institute of botany | Significantly improve the sensory quality and antioxidant capacity of fruits, induce defense response and anthocyanin synthesis, thereby delaying senescence; inhibit the mycelial growth of Botrytis cinerea and Penicillium expansum and reduce the pathogenicity of Botrytis cinerea and Penicillium expansum. | https://patentscope.wipo.int/search/en/detail.jsf?docId=CN307162922 |