Table 17.

Cytotoxic effect of AgNPs.

Shape of AgNPs	Size (nm)	Exposure Time (Hours)	Tumor Model	IC50/LD50(μg/mL)	Normal Cell line	Toxicity mg/L	Ref.
Spherical	20.87	48	Breast Cancer	2.5	373-L1	IC50 = 100	[450]
Spherical	8.19, 8.37	24	Breast Cancer, Epithelioma	49.94, 20.97	NHDF	IC50 > 100	[448]
Spherical	20.44	24	Breast Cancer	65.27	3T3	IC50 = 388.6	[451]
Asymmetric nano dumbbell, Spherical	20.87, 10-16	24, 48	Lung Adenocarcinoma, Oral cancer	–	N1H3T3, HPBM, Rat Hepatocytes	High Toxicity, No toxicity	[452]
Spherical, circular, triangular	5–20	48	Pharynx Cancer	47	Vero and Hbl 1oo	Less toxic than cancer	[453]
Spherical	30–40	24	Ovarian Cancer	A 2780	Human Fibroblast	IC50 = 100 μM	[446]
Spherical	5–15	24	Cervical Cancer	HELA	Normal Renal cell line	Non-toxic	[454]
Spherical	80-98, 30–70, 34-70	48	Prostate Cancer	58.61, 28.42, 42.77	Vero	IC50 = 96.41, 48.83, 48.86	[455]
Spherical	162.72	72, 120	Glioblastoma, Myeloblastic leukemia	6.053	HUVEC, ECV-304	Nontoxic	[456]
Spherical	25	–	Neuroblastoma	–	HVEC	Toxicity to cancer	[447]