Fig. 7.

Spatial mapping of differentially regulated PTM sites.A, heatmap depicting 3D Euclidean distances (in Å) between alpha carbons of select residues in PARP14. B, cropped image of the predicted PARP14 structure highlighting modified residues of interest. The colored residues denote the following: red = cysteine, yellow = lysine, and purple = serine, threonine, or tyrosine. C, line chart showing PTM (or cysteine site) log₂FCs normalized to global protein abundances for PARP14. A decrease in log₂FC for cysteine residues indicates a possibly more reduced thiol state. Log₂FCs for global protein abundances are also included in black.