Table 2.

Relationship of Snail Expression with Histopathological and Tumor Budding Grade

Percent of Snail stained cells
Negative	23	16 (69,6)		2,87 ± 0,44
Characteristics	No. of Patients	Snail positive No. (%)	P value*	(Mean ± SE)	P value
Age (yrs)
<50	20	10 (50)	0.983	5,10 ± 0,62	0,384***
≥50	54	25 (46,3)		4,44 ± 0,43
Gender
Male	39	18 (46,2)	1,000	4,64 ± 0,49	0,987***
Female	35	17 (48,6)		4,60 ± 0,53
Tumor location
Proximal	31	12 (38,7)	0.285	4,00 ± 0,51	0,371**
Distal	31	18 (58,1)		5,23 ± 0,55
Rectum	12	5 (41,7)		4,67 ± 0,36
Histopathological grade
Low	64	47 (73,4)	0.456	4,50 ± 1,02	0,942***
High	10	6 (60)		4,64 ± 0,38
Tumor budding grade
Low	11	2 (18,2)	0,020	1,09 ± 0,89	0,003**
Intermediate	28	11 (39,3)		1,43 ± 0,57
High	35	22 (62,9)		1,97 ± 0,46
LVSI
Positive	60	25 (41,7)	0.087	1,22 ± 0,41	< 0,001***
Negative	14	10 (71,4)		3,43 ± 0,62
Metastases
Positive	51	19 (37,3)	0,020	1,08 ± 0,46	< 0,001***

*, Chi-square test; **, Kruskal Wallis test; ***, Mann Whitney test