. 2024;25(9):2979–2990. doi: 10.31557/APJCP.2024.25.9.2979

Table 1.

Fundamental Features of the Included Studies

Cancer type	First author	Year	Country	Continent	Total number of patients	Number of cases with HER2 and HER3 co- expression	Mean Age or Age Range	Gender	Method of HER2 and HER3 evaluation	JBI
										Score
Breast cancer	Bobrow [27]	1997	UK	European	53	7	-	F:53	IHC	77.7
								M:0
	Suo [28]	2002	Norway	European	97	9	64	F:97	IHC	100
								M:0
	Hudelist [29]	2003	Austria	European	74	59	54.2	F:74	Western blot-analysis	100
								M:0
	Witton [30]	2003	UK	European	220	26	-	F:220	IHC	100
								M:0
	El-Rehim [31]	2004	UK	European	1406	51	53	F:1406	IHC	100
								M:0
	Barnes [32]	2005	UK	European	105	8	55	F:105	IHC	100
								M:0
	Wiseman [33]	2005	Canada	North American	242	2	-	F:242	IHC	88.8
				North American				M:0
	Bianchi [34]	2006	Italy	European	145	40	52.6	F:145	IHC	88.8
								M:40
	Yen [35]	2006	USA	North American	35	12	-	F:35	Western- Blot	88.8
				North American				M:0	Western- Blot
	Kaya [36]	2008	Turkey	European	59	11	59	F:59	IHC	100
								M:0
	Haas [37]	2009	Germany	European	171	41	-	F:171	IHC	100
								M:0
	Gori [38]	2012	Italy	European	61	31	53	F:61	IHC	100
								M:0
	Spears [39]	2012	UK	European	291	124	50.9	F:291	Proximity	100
								M:0	ligation assay
	Spears [40]	2012	UK	European	692	67	-	F:692	IHC	100
								M:0
	Bae [41]	2013	Korea	Asian	235	103	23-77	F:235	IHC	100
								M:0
	Czopek [42]	2013	Poland	European	35	16	54.4	F:35	IHC	88.8
								M:0
	Jerjees [43]	2014	UK	European	1401	92	54	F:1401	IHC	100
								M:0
	Luhtala [44]	2018	Finland	European	308	46	61	F:308	IHC	100
								M:0
	Hassanzadeh Makoui [45]	2024	Iran	Asian	444	53	-	F:441	IHC	100
	Hassanzadeh Makoui [45]							M:3
Biliary tract cancers	Lamarca [46]	2018	UK	European	67	1	65.6	F:35	IHC	77.7
Biliary tract cancers								M:32
Bladder cancer	Chow [47]	2001	China	Asian	245	67	63.3	F:80	IHC	100
								M:165
	Memon [48]	2006	Denmark	European	88	29	72	F:19	RT-PCR	88.8
								M:69
Cancer type	First author	Year	Country	Continent	Total number of patients	Number of cases with HER2 and HER3 co- expression	Mean Age or Age Range	Gender	Method of HER2 and HER3 evaluation	JBI Score
Colorectal cancer	Khelwatty [49]	2014	UK	European	86	20	-	F:37	IHC	100
								M:49
	Seo [50]	2015	Korea	Asian	364	21	-	F:59	IHC	100
								M:305
	Stahler [51]	2017	Germany	European	208	6	-	-	IHC	77.7
	Khelwatty [52]	2021	UK	European	144	109	-	F:43	IHC	100
								M:101
Endometrial cancer	Androutsopoulos [53]	2013	Greece	European	10	9	67.3	-	IHC	77.7
Esophageal	Yoon [54]	2014	USA	North American	224	38	-	F:	IHC	88.8
adenocarcinoma								M:
Esophagogastric adenocarcinoma	Chan [55]	2016	USA	North American	52	18	66	F:10	IHC	88.8
								M:42
Extrahepatic cholangiocarcinoma	Lee [56]	2012	Korea	Asian	224	13	60.9	F:66	IHC	100
								M:164
Gastric Cancer	Lee [57]	2013	Korea	Asian	50	13	61	-	Collaborative Enzyme Enhanced Reactive- immunoassay	66.6
	Ja´come [58]	2014	Brazil	South American	200	23	62	F:77	IHC	100
								M:124
	He [59]	2015	China	Asian	498	25	59	F:148	IHC	100
								M:350
	Tang [60]	2015	China	Asian	121	14	-	F:36	IHC	100
								M:85
	Yun [61]	2018	Korea	Asian	502	13	62	F:170	IHC	100
								M:332
Glioblastoma	Torp [62]	2007	Norway	European	21	8	30-79	F:9	IHC	88.8
								M:12
Head and neck squamous cell carcinoma	Takikita [63]	2011	USA	North American	387	13	61	F:95	IHC	77.7
								M:292
Laryngeal squamous cell carcinoma	Almadori [64]	2021	Italy	European	132	14	-	-	IHC	77.7
Lung cancer	Nishio [65]	2006	Japan	Asian	31	13	62	F:11	IHC	77.7
								M:20
	Sonnweber [66]	2006	Austria	European	79	21	61	F:18	IHC	88.8
								M:60
	Koutsopoulos [67]	2007	Greece	European	209	3	62	F:20	IHC	88.8
								M:189
	Fujita [68]	2008	Japan	Asian	52	7	-	-	IHC	77.7
	Xu [60]	2008	China	Asian	90	13	64	F:46	IHC	100
								M:44
	Xu [70]	2009	China	Asian	106	12	62	F:51	IHC	100
								M:55
	Berghoff [71]	2013	Austria	European	131	7	57	F:	IHC	77.7
								M:
	Siegfried [72]	2015	USA	North American	86	13	68.2	F:57	IHC	100
								M:47
	Manickavasagar [73]	2021	UK	European	45	5	58	F:26	IHC	88.8
								M:19
Cancer type	First author	Year	Country	Continent	Total number of patients	Number of cases with HER2 and HER3 co- expression	Mean Age or Age Range	Gender	Method of HER2 and HER3 evaluation	JBI Score
Nasopharyngeal carcinoma	Tulalamba [74]	2014	Thailand	Asian	82	0	48.67	F:25	IHC	100
								M:57
Neuroblastic tumors	Izycka- Swieszewska [75]	2011	Poland	European	103	37	-	F:103	IHC	100
								M:0
Oral squamous cell carcinoma	Bei [76]	2001	USA	North American	32	10	-	-	IHC	77.7
Osteosarcoma	Wang [77]	2018	China	Asian	60	6	24	F:21	IHC	100
								M:39
Ovarian cancer	Simpson [78]	1995	UK	European	46	34	60	F:46	IHC	88.8
								M:0
	Puvanenthiran [79]	2018	UK	European	60	37	-	F:60	IHC	100
								M:0
Pancreatic cancer	Thomas [80]	2014	France	European	44	5	-	-	IHC	77.7
Papillary thyroid carcinoma	Haugen [81]	1996	Norway	European	56	36	-	-	IHC	66.6
Prostate cancer	Carlsson [82]	2013	China	Asian	12	3	57-74	F:0	IHC	77.7
								M:12
Squamous cell carcinomas of head and neck	O-charoenrat [83]	2002	UK	European	54	20	59.7	F:10	RT-PCR	88.8
								M:44
Squamous cell carcinomas of oral cavity and base of tongue	Ekberg [84]	2005	Sweden	European	19	3	49-82	F:11	IHC	77.7
								M:8
Squamous cell carcinoma of skin	Krahn [85]	2001	Germany	European	5	1	-	-	RT-PCR	66.6
Thymic carcinoma	Weissferdt [86]	2012	USA	North American	24	8	62.3	F:4	IHC	88.8
								M:20