Table 2.
Multivariate Analysis for Factors Predictive of Refractory Disease Post-Induction
| *Parameters | n | CR | No CR | Chi-square p-value | Univariate analysis | Multivariate analysis |
|---|---|---|---|---|---|---|
| Total | 214 | N (%) | N (%) | O. R (95% CI) | O. R (95% CI) | |
| 192 (90) | 22 (10) | |||||
| Age (yrs) | ||||||
| 0-14 | 111 | 108 (97) | 3 (3) | |||
| 15-39 | 85 | 68 (80) | 17 (20) | <0.001 | 9 (2.54-31.86) | 7.34 (1.55-34.77) |
| 40-70 | 18 | 16 (89) | 2 (11) | 4.5 (0.69-29) | 1.15 (0.04-31.9) | |
| Protocol | ||||||
| MCP 841 | 44 | 43 (98) | 1 (2) | |||
| BFM 95 | 92 | 77 (84) | 15 (16) | 8.37 (1.06-65.6) | 2.15 (0.22-20.5) | |
| GMALL | 19 | 15 (79) | 4 (21) | 0.007 | 11.5 (1.2-110.3) | 22.4 (0.8-624) |
| ICICLE | 59 | 57 (97) | 2 (3) | 1.5 (0.13-17.18) | 0.87 (0.06-11.77) | |
| D8 response | ||||||
| Good PR | 189 | 177(94) | 12 (6) | |||
| Poor PR | 25 | 15 (60) | 10 (40) | <0.001 | 9.83 (3.65-26.5) | 8.11 (2.24-29.39) |
| Early ANC nadir (by D15) vs late ANC nadir(>D15) | 76 | 72 (95) | 4 (5) | |||
| 97 | 81 (84) | 16 (16) | 0.03 | 3.57(1.16-10.9) | 5.25 (1.04-26.53) | |
| Platelet Partial Recovery | ||||||
| Early (D22) | 130 | 122 (94) | 8 (6) | |||
| Late (>D22) | 77 | 64 (83) | 13 (17) | 0.013 | 2.89(1.17-7.11) | 1.26 (0.33-4.82) |
Univariate analysis for baseline factors predictive of Refractory disease post-induction is shown in supplementary table 1. Factors found significant in univariate analysis were taken for multivariate analysis. * Abbreviations: CR, complete remission; OR, odds ratio; CI, confidence interval; PR, prednisolone response; ANC, Absolute Netrophil Count