Table 3.
Factors Predicting Event Free Survival (EFS) and Overall Survival (OS) (Cox Regression Analysis for the Entire Cohort).
| Parameters | N= 243 | Median EFS (months) |
3-year EFS(%) | EFS univariate HR (95%CI) |
EFS multivariate HR (95%CI) |
Median OS (months) |
3-year OS (%) | OS univariate HR (95%CI) |
OS multivariate HR (95%CI) |
|
|---|---|---|---|---|---|---|---|---|---|---|
| Age (years) | 0-14 | 116 | Not reached | 61.8 | Not reached | 63.2 | ||||
| 15-39 | 100 | 14.7(8.1-21.2) | 36.4 | 2.19 (1.49-3.23) | 2.01(1.30-3.09) | 19 | 42 | 2.16(1.42-3.29) | 1.9 (1.2-3.0) | |
| 40-70 | 27 | 10.3(0-27.2) | 27 | 3.36 (1.59-5.68) | 2.14(0.98-4.66) | 10.3 | 33.7 | 2.60(1.44-4.68) | 2.2(1-4.7) | |
| 1.22 (0.85-1.75) | ||||||||||
| Sex | Male | 157 | 22.9 | 49.2 | 26.4 | 50 | ||||
| Female | 86 | 18.6(13.4-24) | 43.9 | 19.7(12.1-28.6) | 43.8 | 1.35(0.91-1.99) | ||||
| 1.59 (1.11-2.29) | ||||||||||
| ECOG | 0-1 | 171 | 24.2 | 50.9 | 26.4 | 49.5 | ||||
| >2 | 72 | 15.1(6.6-23.6) | 38.9 | 1.22(0.79-1.92) | 17.7(10-30) | 44 | 1.49(0.99-2.23) | 1.1(0.7-1.8) | ||
| Diagnosis | B-ALL | 172 | 21 | 47.8 | 52.1 | 48.8 | ||||
| T-ALL | 66 | 18.6(12.8-24.4) | 46.9 | 1.24 (0.84-1.84) | 21.1 | 45.9 | 1.135(0.71-1.81) | |||
| Negative | 192 | 21 | 47.1 | 26.4 | 48 | |||||
| Ph+ALL | Positive | 25 | 10.3(6.5-19.4) | 25.2 | 1.82 (1.07-3.09) | 0.74(0.37-1.47) | 12.9(6.4-19.4) | 37.2 | 1.80(1-3.1) | |
| TLC | <50k | 175 | 28.3 | 51 | 39.6 | 53.8 | ||||
| >50k | 68 | 13.1(9.1-17.2) | 30.3 | 1.71 (1.18-2.48) | 1.51(0.99-2.31) | 19.4(12.6-26.2) | 26.4 | 2.105(1.35-3.26) | 1.8(1.1-2.8) | |
| Blasts | 0-20% | 64 | Not reached | 67.3 | Not reached | 72.7 | ||||
| 21-50% | 24 | 22.9 | 22 | 1.53(0.7-3.2) | 24(17.6-30.4) | 44.3 | 1.9(0.9-4.1) | |||
| >51 % | 126 | 19.4(13-26) | 19.4 | 2.0(1.2-3.4) | 26.4(10.2-42.6) | 44.1 | 2.2(1.2-3.9) | |||
| D8 Res | PPR | 216 | 22.9(0.1-47.7) | 47.7 | 10.7 | 31 | ||||
| GPR | 27 | 4.4(0-11.3) | 25.9 | 2.36 (1.46-3.80) | 2.70(1.58-4.63) | 26.4 | 50 | 2.537(1.47-4.37) | 2.3(1.3-4.1) | |
| MRD Status of IA | Negative | 66 | Not reached | 65.6 | Not reached | 65.2 | ||||
| Positive | 19 | 16.9 | 49.3 | 1.65 (0.75-3.65) | Not reached | 59.5 | 1.25(0.52-3.0) | |||
| Platelet partial recovery | Early (D22) | 130 | 56.2 | 62.2 | ||||||
| Late (D23+) | 77 | 17.7(13.7-21.6) | 39.9 | 1.71(1.14-2.55) | 1.63(1.07-2.47) | 21.37(13-29) | 44.1 | 1.74(1.13-2.67) | 1.5 (1-2.4) |
*Factors significant in univariate analysis were taken for multivariate regression.*Abbreviations- EFS, event free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; TLC, total leucocyte count; MRD, minimal residual disease