Table 5.

Diagnostic Performance of Fibroblast Growth Factor 19, Des-γ-carboxy Prothrombin (DCP), and Alpha-Fetoprotein for Diagnosis of HCC and Liver Cirrhosis

Differentiating HCC from Cirrhosis			Differentiating Cirrhosis from Controls
NDLR	0.31	0.17-0.59	0.12	0.04-0.36
	Estimate	95%CI	Estimate	95%CI
FGF-19 (pg/mL)	≥ 140.8		≥ 58.8
Sensitivity	81.80%	68.7%-95.0%	84.80%	72.6%-97.1%
Specificity	87.90%	76.7%-99.0%	90.90%	78.9%-100.0%
PPV	87.10%	75.3%-98.9%	93.30%	84.4%-100.0%
NPV	82.90%	70.4%-95.3%	80.00%	64.3%-95.7%
PDLR	6.75	2.66-17.15	9.33	2.47-35.26
NDLR	0.21	0.10-0.43	0.17	0.07-0.38
DCP (ng/mL)	≥ 0.725		≥ 0.585
Sensitivity	57.60%	40.7%-74.4%	97.00%	91.1%-100.0%
Specificity	51.50%	34.5%-68.6%	90.90%	78.9%-100.0%
PPV	54.30%	37.8%-70.8%	94.10%	86.2%-100.0%
NPV	54.80%	37.3%-72.4%	95.20%	86.1%-100.0%
PDLR	1.19	0.75-1.88	10.67	2.84-40.04
NDLR	0.82	0.49-1.38	0.03	0.01-0.23
AFP (ng/mL)	≥ 13.1		≥ 1.77
Sensitivity	75.80%	61.1%-90.4%	88.90%	77.0%-100.0%
Specificity	77.70%	62.1%-93.5%	90.90%	78.9%-100.0%
PPV	80.60%	66.7%-94.5%	92.30%	82.1%-100.0%
NPV	72.40%	56.1%-88.7%	87.00%	73.2%-100.0%
PDLR	3.4	1.64-7.09	9.78	2.59-36.90

FGF-19, Fibroblast Growth Factor-19; DCP, Des-gamma-carboxy prothrombin; AFP, Alpha-fetoprotein; PPV, Positive predictive value; NPV, Negative predictive value; PDLR, Positive diagnostic likelihood ratio; NDLR, Negative diagnostic likelihood ratio