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. 2025 Jan 4;25:3. doi: 10.1186/s12935-024-03615-8

Table 2.

An overview of various clinical trials examining CAR-Ts against various target antigens for the treatment of solid tumours, including TNBC

Target antigen ClinicalTrials.gov identifier Phase Participants Source Start-completion date
NKG2D ligand NCT04107142 I 10 Allogeneic 2019–2021
ROR1 NCT02706392 I 21 Allogeneic 2016–2021
c-Met

NCT01837602

NCT03060356

I

Early I

6 Allogeneic

2013–2018

2016–2020

Mesothelin

NCT01355965

NCT02580747

NCT02792114

NCT02414269

I

I

I

I/II

77

18

20

186

113

Allogeneic

2011–2015

2015–2018

2016–2023

2015–2024

MUC1 NCT02587689 I/II 20 Allogeneic 2015–2018
A cleaved form of MUC1 NCT04020575 I 69 Allogeneic 2020–2035
TnMUC1 NCT04025216 I 112 Allogeneic 2019–2036