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. 2025 Jan 4;19(1):4. doi: 10.1186/s13065-024-01371-4

Table 7.

Excretion properties of molecules

Desloratadine Levocetirizine Fexofenadine CAPE Quercetin Melatonin Curcumin Vit C
CLplasma 6.872 1.102 0.785 14.184 8.289 7.852 9.635 4.37
T1/2 0.606 1.464 1.206 1.108 1.586 0.839 1.196 2.056

The unit of predicted CLplasma penetration is ml/min/kg. > 15 ml/min/kg: high clearance; 5–15 ml/min/kg: moderate clearance; < 5 ml/min/kg: low clearance

T ½: The unit of predicted T1/2 is hours. ■ ultra-short half-life drugs: 1/2 < 1 h; short half-life drugs: T1/2 between 1–4 h; intermediate short half-life drugs: T1/2 between 4–8 h; long half-life drugs: T1/2 > 8 h