Table 7.
Excretion properties of molecules
Desloratadine | Levocetirizine | Fexofenadine | CAPE | Quercetin | Melatonin | Curcumin | Vit C | |
---|---|---|---|---|---|---|---|---|
CLplasma | 6.872 | 1.102 | 0.785 | 14.184 | 8.289 | 7.852 | 9.635 | 4.37 |
T1/2 | 0.606 | 1.464 | 1.206 | 1.108 | 1.586 | 0.839 | 1.196 | 2.056 |
The unit of predicted CLplasma penetration is ml/min/kg. > 15 ml/min/kg: high clearance; 5–15 ml/min/kg: moderate clearance; < 5 ml/min/kg: low clearance
T ½: The unit of predicted T1/2 is hours. ■ ultra-short half-life drugs: 1/2 < 1 h; short half-life drugs: T1/2 between 1–4 h; intermediate short half-life drugs: T1/2 between 4–8 h; long half-life drugs: T1/2 > 8 h