Table 2.
Tumor characteristics at diagnosisa
| Variable | Undifferentiated carcinoma (n = 32) | Undifferentiated carcinoma with osteoclast-like giant cells (n = 15) | P |
|---|---|---|---|
| Radiologic tumor size, median (IQR), cm | 4.0 (3.0-7.4) | 3.5 (2.6-9.5) | .53 |
| Cancer antigen 19-9, median (IQR), U/mL | 49.0 (18.0-149.7) | 24.0 (13.2-51.8) | .58 |
| Tumor site, No, (%) | .33 | ||
| Ampulla | 1 (3.1) | 1 (6.7) | |
| Body | 9 (28.1) | 5 (33.3) | |
| Head or neck | 16 (50.0) | 9 (60.0) | |
| Tail | 6 (18.8) | 0 (0) | |
| Disease stage, No. (%) | .009 | ||
| Resectable | 13 (40.6) | 12 (80.0) | |
| Borderline resectable | 2 (6.2) | 2 (13.3) | |
| Unresectable | 17 (53.1) | 1 (6.7) | |
| Distant metastasis location, No. (%) | .39 | ||
| Abdominal cavity | 1 (3.1) | 0 (0) | |
| Liver | 6 (18.8) | 1 (6.7) | |
| Lungs | 3 (9.4) | 1 (6.7) | |
| Multiple | 6 (18.8) | 1 (6.7) | |
| None | 16 (50.0) | 12 (80.0) | |
| Cause of death, No. (%) | .006 | ||
| Progression of malignancy | 25 (78.1) | 5 (33.3) | |
| N/A, alive at analysis | 6 (18.8) | 6 (40.0) | |
| Other | 1 (3.1) | 4 (26.7) | |
| Resected, No. (%) | 13 (40.6) | 13 (86.7) | .008 |
| Pathologic tumor size, median (IQR), cm | 4.5 (2.7-5.3) | 4.2 (3.1-11.3) | .10 |
| Operation, No. (%) | .69 | ||
| Pancreaticoduodenectomy | 7 (53.8) | 9 (69.2) | |
| Pancreatectomy | 6 (46.2) | 4 (30.8) | |
| Outcome, No. (%) | .18 | ||
| R0 | 10 (76.9) | 13 (100.0) | |
| R1 | 2 (15.4) | 0 (0) | |
| R2 | 1 (7.7) | 0 (0) |
a
Bold values denote statistical significance. N/A, not applicable; R0, resection margin negative; R1, resection margin microscopically positive; R2, resection margin macroscopically positive.
SI conversion factor: To convert cancer antigen 19-9 to kU/L, mulitply by 1.