REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
K-48 Polyubiquitin	Cell Signaling Technologies	Cat#12805S; RRID:AB_2798031
HSP70	Cell Signaling Technologies	Cat#4876S; RRID:AB_2119693
α-Tubulin	Cell Signaling Technologies	Cat#3873S; RRID:AB_1904178
GAPDH	Abcam	Cat#AC027; RRID:AB_2769572
β-Actin	Cell Signaling Technologies	Cat#3700S; RRID:AB_2242334
Proteasome α6	Purified from hybridoma provided by Tanaka laboratory	Clone Mab 2-17
HA Tag Monoclonal Antibody	Thermo Fisher	Cat#32-6700; RRID:AB_2533092
Anti-rabbit IgG, HRP-linked Antibody	Cell Signaling Technologies	Cat#7074S; RRID:AB_2099233
Anti-mouse IgG, HRP-linked Antibody	Cell Signaling Technologies	Cat#7076S; RRID:AB_330924
Alexa Fluor 647, Goat anti-rabbit IgG (H+L)	Thermo Fisher	Cat#A21245; RRID:AB_2535813
IRDye 800 CW, Goat anti-mouse	LI-COR Biosciences	Cat#926-32210; RRID:AB_621842
Bacterial and virus strains
Rosetta™(DE3) competent cells	Millipore Sigma	Cat#70954
NEB 5-alpha	New England Biolabs	Cat#C2987H
Chemicals, peptides, and recombinant proteins
LU-102	Provided by Overkleeft lab	CAS#1421639-62-4
Bortezomib	LC Laboratories	Cat#B-1408
Carfilzomib	LC Laboratories	Cat#C-3022
Ibrutinib	MedChemExpress	Cat#HY-10997
Acalabrutinib	MedChemExpress	Cat#HY-17600
ONO-4059	MedChemExpress	Cat#HY-15771
CC-292	MedChemExpress	Cat#HY-18012
CGI-1746	MedChemExpress	Cat#HY-11999
GDC-0853	MedChemExpress	Cat#HY-19834
Evobrutinib	MedChemExpress	Cat#HY-101215
Zanubrutinib	MedChemExpress	Cat#HY-101474A
Ac-DEVD-AMC (N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin)	Bachem	Cat#I-1660
Suc-LLVY-AMC	Bachem	Cat#1-1395
Ac-RLR-AMC	ChinaPeptide	Custom synthesis
Ac-nLPnLD-AMC	ChinaPeptide	Custom synthesis
NMS-873	Selleckchem	Cat#S7285
HA-Ub-VS	Enzo Life Sciences	Cat#BML-UW0155-0025
Alamar Blue	Thermo Fisher	Cat#DAL1025
Critical commercial assays
SuperSignal™ West Femto Maximum Sensitivity Substrate	Thermo Fisher	Cat#34095
CellEvent™ Caspase 3/7 Green Detection Reagent	Thermo Fisher	Cat#C10423
SYTOX™ Red Dead cell stain	Thermo Fisher	Cat#S34859
GSH/GSSG-Glo™ Assay	Promega	V6611
ADP-Glo™ Kinase Assay	Promega	Cat#V6930
Phosphostain	Thermo Fisher	Cat#P33301
GelCode™ Blue Safe Protein Stain	Thermo Fisher	Cat#1860957
RNeasy Mini Kit	Qiagen	Cat#74104
Deposited data
Raw and analyzed RNA sequencing data	This paper	GSE239482
Full Western Blots	This paper	https://doi.org/10.17632/7n36xfmfj9.1
Experimental models: Cell lines
MDA-MB-231	ATCC	RRID:CVCL_0062
MDA-MB-468	ATCC	RRID:CVCL_0419
SUM149	Asterand	RRID:CVCL_3422
INA-6	DSMZ	RRID:CVCL_5209
MM1.S	Dr. Steven Rosen	RRID:CVCL_8792
Raji	ATCC	RRID:CVCL_0511
NCI-H929	ATCC	RRID:CVCL_1600
Recombinant DNA
pDEST15-UBL-hHR23B	Dr. Alfred Goldberg
pET26b-His10-UIM2-hS5a	Dr. Alfred Goldberg
Software and algorithms
Prism	GraphPad
CalcuSyn	Biosoft