Table 1.
Patient characteristics.
| Characteristics | All (n =15) | Cushing’s disease (n =7) | Adrenal Cushing’s syndrome (n =8) | p value |
|---|---|---|---|---|
| age, y.o. | 51.7 (39.0 – 64.0) | 61.0 (54.0 – 65.5) | 39.0 (33.5 – 54.0) | 0.049 |
| sex | F/M 13/2 | F/M 6/1 | F/M 7/1 | 1.0† |
| height, m | 1.5 (1.5 – 1.6) | 1.5 (1.4 – 1.5) | 1.5 (1.5 – 1.6) | 0.41 |
| body weight, kg | 65.3 (52.4 – 74.8) | 60.0 (48.9 – 74.5) | 72.7 (59.0 – 74.3) | 0.48 |
| BMI, kg/m2 | 26.5 (22.6 – 30.8) | 25.8 (22.2 – 29.9) | 25.6 (23.2 – 30.9) | 0.64 |
| BSA, m2 | 1.6 (1.5 – 1.8) | 1.5 (1.4 – 1.7) | 1.7 (1.5 – 1.8) | 0.56 |
| early morning serum cortisol, nmol/L | 604.1 (506.2 – 634.4) | 642.7 (622.0 – 839.9) | 535.1 (486.2 – 571.0) | 0.024 |
| late-night serum cortisol, nmol/L | 556.2 (437.2 – 649.6) | 664.8 (506.2 – 815.1) | 528.2 (451.7 – 567.5) | 0.13 |
| serum cortisol after LDDST, nmol/L | 593.0 (562.7 – 682.7) | 706.2 (573.7 – 1246.8) | 580.6 (515.8 – 621.3) | 0.11 |
| UFC, fold-change of ULN | 6.1 (3.7 – 14.5) | 16.5 (5.1 – 19.6) | 4.89 (3.8 – 6.2) | 0.083 |
Data are presented as median (IQR).
Each parameter for the groups of Cushing’s disease and adrenal Cushing’s syndrome was tested using the Mann-Whitney U test.
† For the categorical data, a Fisher's exact test was used to calculate the odds ratio and p value. The odds ratio was 0.85.
BMI, body mass index; BSA, body surface area; LDDST, low-dose dexamethasone suppression test; UFC, urinary free cortisol;
ULN, multiples of the upper limit of normal; F, female; M, male; IQR, interquartile range.