Table 2.
Categorical analysis on the correlation between risk factors for T2DM and GDM.
| Risk factors | No. of studies | Heterogeneity | Effective models | OR (95% CI) | Z | p | |
|---|---|---|---|---|---|---|---|
| I² (%) | p | ||||||
| Demographic and lifestyle characteristics | |||||||
| Age | 12 | 95.9 | 0.000 | Random | 1.71 (1.23, 2.38) | 3.18 | 0.001 |
| Family history of diabetes | 9 | 42.4 | 0.085 | Random | 1.60 (1.26, 2.04) | 3.8 | <0.001 |
| Use of progestin-only contraceptive | 3 | 61 | 0.077 | Random | 2.12 (1.00, 4.45) | 1.97 | 0.049 |
| Breastfeeding | 2 | 0.0 | 0.87 | Fixed | 0.81 (0.39, 1.68) | 0.56 | 0.573 |
| Greater education | 4 | 62.7 | 0.045 | Random | 0.53 (0.20, 1.37) | 1.32 | 0.188 |
| Asian | 3 | 0.0 | 0.538 | Fixed | 6.22 (4,97, 7.79) | 15.91 | <0.001 |
| White | 2 | 75.5 | 0.043 | Random | 5.52 (3.96, 7.69) | 10.08 | <0.001 |
| Hispanic | 2 | 0.0 | 0.434 | Fixed | 7.75 (6.86, 8.76) | 32.84 | <0.001 |
| African American | 2 | 67.4 | 0.080 | Random | 8.38 (6.35, 11.05) | 15.02 | <0.001 |
| Pregnancy-related factors | |||||||
| Weight change | 3 | 65 | 0.057 | Random | 1.03 (0.90, 1.19) | 0.46 | 0.647 |
| Parity | 2 | 56.5 | 0.129 | Random | 1.12 (0.84, 1.49) | 0.79 | 0.432 |
| Waist circumference | 4 | 86.8 | 0.000 | Random | 1.12 (0.98, 1.29) | 1.68 | 0.094 |
| Macrosomia | 3 | 0.0 | 0.671 | Fixed | 3.30 (1.45, 7.49) | 2.85 | 0.004 |
| Neonatal birth weight | 3 | 74.3 | 0.049 | Random | 1.22 (0.74, 2.00) | 0.77 | 0.442 |
| Insulin use in pregnancy | 14 | 82.6 | 0.000 | Random | 4.35 (3.17, 5.96) | 9.13 | <0.001 |
| Early diagnosis GDM | 5 | 46.1 | 0.115 | Fixed | 0.96 (0.93, 0.99) | 1.13 | 0.26 |
| GDM recurrence | 4 | 0.0 | 0.476 | Fixed | 2.63 (1.88, 3.69) | 5.62 | <0.001 |
| Hypertension | 4 | 96.6 | 0.000 | Random | 5.19 (1.31, 20.51) | 2.35 | 0.019 |
| Gestational interval | 2 | 0.0 | 0.606 | Fixed | 1.68 (1.09, 2.58) | 2.37 | 0.018 |
| Pre-pregnancy BMI | 15 | 93.8 | 0.000 | Random | 2.93 (2.11, 4.07) | 6.44 | <0.001 |
| BMI in pregnancy | 5 | 70.1 | 0.010 | Random | 1.26 (0.99, 1.60) | 1.91 | 0.056 |
| BMI after delivery | 9 | 99.5 | 0.000 | Random | 4.58 (2.87, 7.30) | 6.38 | <0.001 |
| Laboratory indicators | |||||||
| HbA1c | 3 | 0.0 | 0.609 | Fixed | 3.32 (1.81, 6.11) | 3.86 | <0.001 |
| FBG | 12 | 96 | 0.000 | Random | 1.58 (1.36, 1.84) | 5.91 | <0.001 |
| OGTT 1-h | 4 | 99.5 | 0.000 | Random | 1.38 (1.02, 1.87) | 2.08 | 0.037 |
| OGTT 2-h | 8 | 80 | 0.000 | Random | 1.54 (1.28, 1.85) | 4.62 | <0.001 |