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. 2024 Dec 23;15:1486861. doi: 10.3389/fendo.2024.1486861

Table 2.

Categorical analysis on the correlation between risk factors for T2DM and GDM.

Risk factors No. of studies Heterogeneity Effective models OR (95% CI) Z p
I² (%) p
Demographic and lifestyle characteristics
Age 12 95.9 0.000 Random 1.71 (1.23, 2.38) 3.18 0.001
Family history of diabetes 9 42.4 0.085 Random 1.60 (1.26, 2.04) 3.8 <0.001
Use of progestin-only contraceptive 3 61 0.077 Random 2.12 (1.00, 4.45) 1.97 0.049
Breastfeeding 2 0.0 0.87 Fixed 0.81 (0.39, 1.68) 0.56 0.573
Greater education 4 62.7 0.045 Random 0.53 (0.20, 1.37) 1.32 0.188
Asian 3 0.0 0.538 Fixed 6.22 (4,97, 7.79) 15.91 <0.001
White 2 75.5 0.043 Random 5.52 (3.96, 7.69) 10.08 <0.001
Hispanic 2 0.0 0.434 Fixed 7.75 (6.86, 8.76) 32.84 <0.001
African American 2 67.4 0.080 Random 8.38 (6.35, 11.05) 15.02 <0.001
Pregnancy-related factors
Weight change 3 65 0.057 Random 1.03 (0.90, 1.19) 0.46 0.647
Parity 2 56.5 0.129 Random 1.12 (0.84, 1.49) 0.79 0.432
Waist circumference 4 86.8 0.000 Random 1.12 (0.98, 1.29) 1.68 0.094
Macrosomia 3 0.0 0.671 Fixed 3.30 (1.45, 7.49) 2.85 0.004
Neonatal birth weight 3 74.3 0.049 Random 1.22 (0.74, 2.00) 0.77 0.442
Insulin use in pregnancy 14 82.6 0.000 Random 4.35 (3.17, 5.96) 9.13 <0.001
Early diagnosis GDM 5 46.1 0.115 Fixed 0.96 (0.93, 0.99) 1.13 0.26
GDM recurrence 4 0.0 0.476 Fixed 2.63 (1.88, 3.69) 5.62 <0.001
Hypertension 4 96.6 0.000 Random 5.19 (1.31, 20.51) 2.35 0.019
Gestational interval 2 0.0 0.606 Fixed 1.68 (1.09, 2.58) 2.37 0.018
Pre-pregnancy BMI 15 93.8 0.000 Random 2.93 (2.11, 4.07) 6.44 <0.001
BMI in pregnancy 5 70.1 0.010 Random 1.26 (0.99, 1.60) 1.91 0.056
BMI after delivery 9 99.5 0.000 Random 4.58 (2.87, 7.30) 6.38 <0.001
Laboratory indicators
HbA1c 3 0.0 0.609 Fixed 3.32 (1.81, 6.11) 3.86 <0.001
FBG 12 96 0.000 Random 1.58 (1.36, 1.84) 5.91 <0.001
OGTT 1-h 4 99.5 0.000 Random 1.38 (1.02, 1.87) 2.08 0.037
OGTT 2-h 8 80 0.000 Random 1.54 (1.28, 1.85) 4.62 <0.001