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Scheme illustrating the working system of PFC@PEPP-Fe generating cancer-specific “OFF-ON” signals for activatable bimodal FL and US imaging at (A) physiological pH (below 37 ℃) and (B) endosomal pH (above 37 ℃). (C) Schematic illustration demonstrates the cancer treatment process of PFC@PEPP-Fe through combination of enhanced-CDT and PTT following cancer cell uptake facilitated by the EPR effect.
