Figure 5.
Metformin-based nanomedicine in combination with radiotherapy. (A) Schematic illustration of Met@HMnER to inhibit cancer recurrence and metastasis in the MCF7 tumor-bearing mice. Created in https://BioRender.com. (B) Fluorescence microscope images for ATM and γ-H2AX. Elevation in the expression of both of them indicated significant DNA damage and enhanced radiotherapy sensitization after treatment with Met@HMnER. (C) The expression levels of IFN-γ secreted by NK cells through activating the cGAS-STING pathway by Met@HMnER. (D) Photos of lungs (above) and recurrent tumors (below) after treatment with Met@HMnER, confirming its anti-recurrence and anti-metastasis efficacy. Adapted with permission from 138, copyright 2023 Elsevier Ltd.