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. 2025 Jan 6;41(1):22. doi: 10.1007/s10565-024-09977-z

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — RNF112 may be involved in CRC tumorigenesis. The data from mRNA sequencing, GSE200427 and GSE196006 profiles were collected, and total DEGs were used for bioinformatics analysis. A The ring heat map and volcano map showed the expression of genes in the three datasets. B GO and KEGG analysis were performed on the total DEGs. C The upset plot showed the intersection of the correlation analysis between three datasets. D Venn diagram showed the common DEGs in the three datasets. The common DEGs of the three datasets were then intersected with genes related to E3 Ubiquitin ligase in GeneCards and ubiquitin ligase coding and related genes in UALACN database. Venn diagram showed the shared DEGs