Table 4.

Comparison of ApoE alleles and genotypes frequencies between the control and LUAD different stages subgroups with different stages.

Allele, Genotype	Control (N =400)	Early (N =95)	p-Value	Advanced (N=105)	p-Value
ϵ2 allele, n (%)	56(7%)	22(11.6%)	0.003	40(21.2%)	0.003
ϵ3 allele, n (%)	655(81.9%)	161(84.7%)	0.366	166(87.4%)	0.370
ϵ4 allele, n (%)	89(11.1%)	7(3.7%)	0.003	4(2.1%)	0.000
ApoE ϵ2ϵ2	9(2.3%)	5(5.3%)	0.110	11(10.5%)	0.001
ApoE ϵ2ϵ3	17(4.3%)	9(9.5%)	0.040	16(15.2%)	0.000
ApoE ϵ3ϵ3	294(73.5%)	75(78.9%)	0.297	74(70.5%)	0.535
ApoE ϵ2ϵ4	21(5.3%)	3(3.2%)	0.393	2(1.9%)	0.191
ApoE ϵ3ϵ4	50(12.5%)	2(2.1%)	0.003	2(1.9%)	0.002
ApoE ϵ4ϵ4	9(2.3%)	1(1.1%)	0.695	0(0%)	0.215

Bold P-values indicate statistically significant differences (P < 0.05).