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. 2024 Dec 27;29:74. doi: 10.1265/ehpm.24-00139

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Arsenite exposure in Huh-7 cells upregulated genes encoding SASP factors

A) Changes in the gene expressions of SASP factors in the Huh-7 cells after arsenite exposure. The mRNA expression level of each gene was quantified by real-time PCR and normalized to the expression level of RPLP1. The bar graph shows the relative gene expression level of each SASP factor after 72 h of arsenite exposure. Data are presented as the means ± SEM (n = 3). The two-tailed unpaired Student’s t-test was used for statistical analysis. **, ***, ****significantly different from the control; **P < 0.01, ***P < 0.001, ****P < 0.0001. B) Representative bright field images and immunofluorescence staining images of MMP3 and Hoechst 33342 in Huh-7 cells with or without 75 hours of sodium arsenite exposure (left panel). Quantitative result using data from 5 randomly selected fields of view (right panel). The two-tailed unpaired Student’s t-test was used for statistical analysis. ***significantly different from the control; ***P < 0.001.