Figure 3.

Distribution of hiNSC in immunodeficient Idua^−/− mice 8 months post-transplantation

Immunohistochemical staining of STEM121 is shown in representative animal images. Positive STEM121 signal was observed in olfactory bulb (OB), midbrain (MB), cerebellum (CB), and pons/medulla (P/MD). Full brain scan images (top) and selected regions of interest (bottom) show broad distribution of engrafted hiNSCs across multiple brain regions. For each full-brain image, selected regions below (left) are 10× magnification and further expanded to 40× magnification for detailed examination (right). Scale bars, 50 μm.