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. 2024 Dec 23;17:1487364. doi: 10.3389/fnmol.2024.1487364

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Copyright © 2024 Tian, Huang, Xiao, Jiang, Ma, Lin, Tang, Wang, Dai, Tong, Ye, Sheng, Chai and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IDPN treatment causes more severe HCs damage than neomycin. (A,B) Schematic diagram of the in vivo IDPN damage model (A) and in vivo neomycin damage model (B). (C,D) Images (C) and statistical analysis of HCs number (D) of Striola (S) and Exstriola (ES) region of the utricle treated by neomycin and IDPN. Myo7a stained in red is used as HCs marker. Scale bar is 20 μm in (C) *p < 0.05, **p < 0.01, ***p < 0.001, ns, no significant difference. The number of mice (N) is shown in parentheses.