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. Author manuscript; available in PMC: 2026 Jan 2.
Published in final edited form as: Cell Stem Cell. 2024 Nov 4;32(1):86–104.e7. doi: 10.1016/j.stem.2024.10.005

Figure 2. PLX depletes microglia, but does not affect astrocytes, in chimeric mouse hippocampus.

Figure 2.

(A) Representative images of microglia (Iba1, red) in the hippocampus of chimeric mice of each condition. Scale bar, 500 μm.

(B) Quantification of number/mm2 of Iba1+ microglia in the hippocampus. Each dot represents one mouse (hE3-E3KI, n=5; hE3-E3KI-PLX, n=7; hE4-E4KI, n=9; hE4-E4KI-PLX, n=8; hEKO-E4KI, n=4; hEKO-E4KI-PLX, n=6).

(C) Representative images of astrocytes (GFAP, red) in the hippocampus of chimeric mice of each condition. Scale bar, 500 μm.

(D) Quantification of number/mm2 of GFAP+ astrocytes in the hippocampus. Each dot represents one mouse (hE3-E3KI, n=5; hE3-E3KI-PLX, n=7; hE4-E4KI, n=9; hE4-E4KI-PLX, n=8; hEKO-E4KI, n=4; hEKO-E4KI-PLX, n=6).

All data are expressed as mean ± S.E.M. Differences between groups were determined by two-way ANOVA with Benjamini’s post hoc test for multiple comparisons. Adjusted p-values (q-values) are displayed.