Table 4.
Clinical characteristics and detailed information of the blood culture results of ddPCR-positive patients with and without septic shock
| All patients (n = 67) | Patients with septic shock (n = 17) | Patients without septic shock (n = 50) | P value | |
|---|---|---|---|---|
| Age (years), median (IQR) | 75 (60–82) | 77 (73–84) | 75 (68–82) | 0.77 |
| Male, n (%) | 38 (56.7) | 10 (58.8) | 28 (56.0) | 0.84 |
| Primary site of BSI | ||||
| Abdominal infection, n (%) | 38 (56.7) | 8 (47.1) | 30 (60.0) | 0.35 |
| Bile duct infection, n (%) | 30 (44.8) | 3 (17.7) | 27 (52.3) | 0.011 |
| Intestinal perforation, n (%) | 5 (7.5) | 5 (29.4) | 0 (0) | < 0.001 |
| Urinary tract infection, n (%) | 24 (35.8) | 7 (41.2) | 17 (34.0) | 0.59 |
| Others, n (%) | 5 (7.5) | 2 (11.8) | 3 (6.0) | 0.59 |
| BSI caused by ESBL-producing E. coli, n (%) | 15 (22.4) | 6 (35.3) | 9 (18.0) | 0.14 |
| E. coli DNA load in whole blood (copies/mL), median (IQR) | 362 (200–834) | 6500 (1106–17512) | 312 (138–506) | < 0.001 |
| 28-day mortality, n (%) | 8 (11.9) | 8 (47.1) | 0(0) | < 0.001 |
| Blood culture | ||||
| TTP (h), median (IQR) | 8.8 (8.3–10.1) | 8.2 (5.7–8.7) | 9.3 (8.5–10.3) | < 0.001 |
| Positive for two sets of blood culture, n (%) | 60 (89.6) | 17(100) | 43 (86.0) | 0.18 |
| No. of positive bottle of two sets of blood culture | ||||
| 4 bottles, n (%) | 48 (71.6) | 17(100) | 31 (62.0) | 0.016 |
| 3 bottles, n (%) | 7 (10.5) | 0 (0) | 7 (14.0) | 0.18 |
| 2 bottles, n (%) | 10 (14.3) | 0 (0) | 10 (20.0) | 0.055 |
| 2 bottles of different sets, n (%) | 5 (7.5) | 0 (0) | 5 (10.0) | 0.56 |
| 1 bottle, n (%) | 2 (3.0) | 0 (0) | 2 (4.0) | 1.0 |
ESBL, extended-spectrum β-lactamase; IQR, interquartile range; TTP, time-to-positivity