TABLE 1.
Clinical statistics of intracytoplasmic sperm injection (ICSI) attempts in affected individuals.
| Patient | Age (year) | Infertility duration (year) | ICSI cycles | ICSI with AOA cycles | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Insemination method | Total oocyte | MII oocyte | Fertilized outcomes (2PN + 1PN + MPN + 0PN) | Normal fertilization rate (%) | D3 Cleaved embryo | Embryo outcomes | Good‐quality embryo rate (%) | Insemination method | Total oocyte | MII oocyte | Fertilized outcomes (2PN + 1PN + MPN + 0PN) | Normal fertilization rate (%) |
D3 Cleaved embryo |
Embryo outcomes | Good‐quality embryo rate (%) | |||
| Family 1 II‐1 | 27 | 3 | ICSI | 25 | 21 | 3 + 1 + 0 + 17 | 3/21 (14.29) | 18 | 17 arrested 1*4CC (D6) | 0/18 (0.00) | ICSI + AOA | 24 | 22 | 19 + 2 + 0 + 1 | 19/22 (86.36) | 20 |
10 arrested 1*7CELL II 3*8CELL II 2*10CELL II 1*5CB (D5) 1*4CB (D5) 1*6BB (D5) 1*4CC (D5) |
7/20 (35.0) |
| Family 2 II‐1 | 51 | 11 | ICSI | 11 | 11 |
Unknown 3 in total |
Unknown | Unknown | Unknown | Unknown | ICSI + AOA | 5 | 5 | 3 + 1 + 0 | 3/5 (60.0) | 3 | 2 arrested 1*10CELL II | 1/3 (33.33) |
| ICSI + AOA | 1 | 1 | 1 + 0 + 0 | 1/1 (100.0) | 1 | 1*8CELL II‐ | 1/1 (100.0) | |||||||||||
Abbreviations: AOA, artificial oocyte activation; MII, metaphase II; MPN, multipronucleus.