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[Preprint]. 2024 Dec 17:2024.12.13.628322. [Version 1] doi: 10.1101/2024.12.13.628322

Figure 4: Comparison of protein domains and amino acid alignment of canonical TNS1 and eTNS1.

Figure 4:

(A) Comparison of canonical TNS1 (TNS1-201) protein domains to eTNS1 (TNS1-208). The amino acids in pink are unique to eTNS1, while the 21 amino acids in gray (1000-1020) in canonical TNS1 are missing in eTNS1. The primary antibody epitope is indicated (amino acids 1326-1339 in TNS1). Schematic created with BioRender.com. (B) Amino acid alignment using UniProt align tool showing amino acids coded for by exon 1E in eTNS1 protein, highlighted in pink. Asterisks, identical residues; Colon, residues with strongly similar properties (scoring > 0.5 in Gonnet PAM 250 matrix); Period, residues with weakly similar properties (scoring < 0.5 in Gonnet PAM 250 matrix).