Table 1.
Demographic and clinical data of the studied patients.
| All patients N = 71 |
Groups | P value | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Group 1.1 and 1.2 N = 39 |
Group 1.4.4 N = 27 |
Group 5 N = 5 |
|||||||
| Age | |||||||||
| Minimum–maximum | 5.00–228.00 | 12.00–228.00 | 5.00–216.00 | 24.00–144.00 | 0.75 | ||||
| Mean – SD | 91.04 ± 52.34 | 86.97 ± 47.68 | 99.11 ± 59.58 | 79.20 ± 49.91 | |||||
| Median | 84.00 | 84.00 | 84.00 | 84.00 | |||||
| IQR | 54.00 to 130.50 | 46.50 to 120.00 | 54.50 to 162.00 | 33.00 to 117.00 | |||||
| Gender | No. | % | No. | % | No. | % | No. | % | |
| Male | 29 | 40.8 | 17 | 43.6 | 10 | 37 | 2 | 40 | 0.87 |
| Female | 42 | 59.2 | 22 | 56.4 | 17 | 63 | 3 | 60 | |
| Height | |||||||||
| Minimum–maximum | 62.00–159.00 | 74.00–159.00 | 62.00–147.00 | 81.00–130.00 | 0.78 | ||||
| Mean – SD | 115.21 ± 22.94 | 116.35 ± 22.97 | 113.92 ± 23.75 | 113.00 ± 22.43 | |||||
| Median | 117.00 | 119.00 | 110.00 | 120.50 | |||||
| IQR | 97.50 to 132.00 | 100.00 to 132.00 | 95.00 to 140.00 | 97.50 to 128.50 | |||||
| Weight | |||||||||
| Minimum–maximum | 4.50–60.00 | 8.00–60.00 | 4.50–45.00 | 6.50–33.00 | 0.88 | ||||
| Mean – SD | 22.47 ± 11.88 | 22.72 ± 12.74 | 22.57 ± 11.04 | 19.90 ± 11.15 | |||||
| Median | 20.00 | 20.00 | 22.00 | 21.00 | |||||
| IQR | 13.00 to 29.50 | 13.25 to 27.25 | 13.00 to 30.00 | 9.87 to 29.25 | |||||
| Syncope | No. | % | No. | % | No. | % | No. | % | |
| No syncope | 58 | 81.7 | 26 | 66.7 | 27 | 100 | 5 | 100 | a0.0015 |
| Syncope | 13 | 19.3 | 13 | 33.3 | 0 | 0 | 0 | 0 | |
| Cyanosis | No. | % | No. | % | No. | % | No. | % | |
| No cyanosis | 54 | 76.1 | 37 | 94.9 | 12 | 44.4 | 5 | 100 | a<0.0001 |
| Cyanosis | 17 | 23.9 | 2 | 5.1 | 15 | 55.6 | 0 | 0 | |
| Dyspnea | No. | % | No. | % | No. | % | No. | % | |
| No Dyspnea | 6 | 8.5 | 3 | 8 | 3 | 11.1 | 0 | 0 | 0.69 |
| Dyspnea | 65 | 91.5 | 36 | 92.3 | 24 | 88.9 | 5 | 100 | |
| WHO FC | No. | % | No. | % | No. | % | No. | % | |
| WHO FC 1 | 8 | 11.3 | 5 | 12.8 | 3 | 11.1 | 0 | 0 | 0.06 |
| WHO FC 2 | 39 | 54.9 | 16 | 41 | 21 | 77.8 | 2 | 40 | |
| WHO FC 3 | 14 | 19.7 | 11 | 28.2 | 1 | 3.7 | 2 | 40 | |
| WHO FC 4 | 10 | 14.1 | 7 | 18 | 2 | 7.4 | 1 | 20 | |
| O 2 Sat | |||||||||
| Minimum–maximum | 0.65–1.00 | 0.70–1.00 | 0.65–0.99 | 0.88–0.96 | a0.000159 | ||||
| Mean – SD | 0.92 ± 0.075 | 0.94 ± 0.06 | 0.88 ± 0.08 | 0.93 ± 0.038 | |||||
| Median | 0.94 | 0.96 | 0.89 | 0.94 | |||||
| IQR | 0.88 to 0.97 | 0.94 to 0.98 | 0.86 to 0.91 | 0.89 to 0.96 | |||||
| Clubbing | No. | % | No. | % | No. | % | No. | % | |
| No clubbing | 57 | 80.3 | 37 | 94.8 | 16 | 59.3 | 4 | 80 | a0.0055 |
| Grade 1 | 6 | 6 | 2 | 5.1 | 4 | 14.8 | 0 | 0 | |
| Grade 2 | 8 | 11.3 | 0 | 0.0 | 7 | 25.9 | 1 | 20 | |
| RV failure | No. | % | No. | % | No. | % | No. | % | |
| No RV failure | 48 | 67.6 | 24 | 61.5 | 23 | 85.2 | 1 | 20 | *0.0081 |
| RV failure | 23 | 32.4 | 15 | 38.5 | 4 | 14.8 | 4 | 80 | |
| 6MWD | |||||||||
| Minimum–maximum | 40.00–540.00 | 40.00–450.00 | 60.00–540.00 | 100.00–418.00 | 0.17 | ||||
| Mean – SD | 273.32 ± 139.99 | 242.73 ± 136.38 | 316.80 ± 137.05 | 289.33 ± 167.45 | |||||
| Median | 300.00 | 256.00 | 355.00 | 350.00 | |||||
| IQR | 150.00 to 390.00 | 100.00 to 380.00 | 180.00 to 413.00 | 162.50 to 401.00 | |||||
| 6MWD (age adjusted) | |||||||||
| Minimum–maximum | −10.00–0.50 | −10.00–0.50 | −10.00–−0.40 | −9.56–−2.40 | 0.33 | ||||
| Mean – SD | −4.89 ± 2.72 | −5.31 ± 2.65 | −4.17 ± 2.70 | −5.45 ± 3.69 | |||||
| Median | −4.88 | −5.38 | −4.11 | −4.40 | |||||
| IQR | −6.84 to −2.86 | −7.25 to −2.98 | −4.93 to −2.21 | −8.27 to −2.90 | |||||
| 6MWD (height adjusted) | |||||||||
| Minimum–maximum | −9.50–1.48 | −9.28–1.00 | −9.50–1.48 | −7.90–−2.70 | 0.40 | ||||
| Mean – SD | −4.20 ± 2.53 | −4.57 ± 2.40 | −3.59 ± 2.69 | −4.52 ± 2.92 | |||||
| Median | −3.59 | −4.41 | −3.09 | −2.98 | |||||
| IQR | −5.92 to −2.68 | −6.35 to −2.69 | −4.17 to −2.57 | −6.67 to −2.77 | |||||
| NT Pro-BNP | |||||||||
| Minimum–maximum | 20.00–15000.00 | 20.00–15000.00 | 25.20–15000.00 | 479.80–5019.00 | 0.58 | ||||
| Mean – SD | 3553.79 ± 4101.02 | 4101.82 ± 4140.68 | 3107.19 ± 4305.48 | 1910.12 ± 1900.59 | |||||
| Median | 1982.00 | 2405.40 | 1234.10 | 1033.00 | |||||
| IQR | 373.92 to 5472.00 | 304.37 to 6160.40 | 368.37 to 4423.47 | 571.30 to 3067.50 | |||||
| NT Pro-BNP z score | |||||||||
| Minimum–maximum | −1.48–6.99 | −1.48–6.23 | −0.69–6.99 | 2.51–5.18 | 0.51 | ||||
| Mean – SD | 3.57 ± 1.91 | 3.69 ± 2.09 | 3.42 ± 1.82 | 3.50 ± 1.08 | |||||
| Median | 3.94 | 4.39 | 3.33 | 3.00 | |||||
| IQR | 2.42 to 5.07 | 1.84 to 5.38 | 2.60 to 4.76 | 2.77 to 4.25 | |||||
| Outcome | No. | % | No. | % | No. | % | No. | % | |
| Morbidity | 16 | 22.5 | 8 | 20.5 | 5 | 18.5 | 3 | 60 | 0.32 |
| Mortality | 17 | 23.9 | 10 | 25.6 | 6 | 22.2 | 1 | 20 | |
p: p value for comparing between the different studied groups.
*
Statistically significant at p ≤ 0.05.