Table 4.
Prognostic performance of the ROC curve to predict the morbidity and mortality.
| AUC | P | 95 % C.I | Cut off value | Sensitivity % | Specificity % | PPV | NPV | |
|---|---|---|---|---|---|---|---|---|
| Mortality | ||||||||
| 6MWD | 0.739 | *0.0102 | 0.600 to 0.850 | ≤210 | 72.73 | 73.81 | 42.1 | 91.2 |
| 6MWD adjusted to height | 0.669 | 0.07 | 0.526 to 0.792 | ≤−5.11 | 54.55 | 76 | 37.5 | 86.5 |
| NT pro BNP | 0.809 | *<0.0001 | 0.696 to 0.894 | >4734 | 76.47 | 80.77 | 56.5 | 91.3 |
| NT pro-BNP z score | 0.802 | *<0.0001 | 0.689 to 0.888 | >4.57 | 76.47 | 73.08 | 48.1 | 90.5 |
| WHO Functional class | 0.716 | *0.0024 | 0.597 to 0.817 | >3 | 47.03 | 96.3 | 80.0 | 85.2 |
| RA area z score | 0.630 | 0.167 | 0.502 to 0.749 | >4.9 | 37.50 | 95.9 | 75.0 | 82.5 |
| RV/LV ratio | 0.733 | *0.0014 | 0.608 to 0.835 | >0.85 | 93.75 | 44.90 | 35.7 | 95.7 |
| TAPSE | 0.733 | *0.0002 | 0.611 to 0.834 | ≤15 | 93.75 | 49.02 | 36.6 | 96.2 |
| RV failure | 0.751 | *<0.0001 | 0.634 to 0.846 | 70.59 | 79.63 | 52.2 | 89.6 | |
| Morbidity | ||||||||
| WHO Functional class | 0.835 | *<0.0001 | 0.709 to 0.922 | >2 | 75.00 | 92.11 | 80 | 89.7 |
| 6MWD | 0.683 | *0.1101 | 0.521 to 0.818 | ≤220 | 70.00 | 84.37 | 58.3 | 90 |
| RV failure | 0.755 | *0.0001 | 0.619 to 0.862 | 56.25 | 94.74 | 81.8 | 83.7 | |
| TAPSE | 0.776 | *0.0003 | 0.637 to 0.881 | ≤15 | 75.00 | 77.14 | 60.0 | 87.1 |
| NT pro-BNP | 0.755 | *0.0008 | 0.616 to 0.864 | >1032 | 80.00 | 62.16 | 46.2 | 88.5 |
| NT pro BNP z score | 0.737 | *0.0019 | 0.596 to 0.849 | >3.5 | 73.33 | 67.57 | 47.8 | 86.2 |
AUC: Area under the curve, 6MWD: 6 min walking distance, NT pro-BNP: N terminal pro-brain natriuretic peptide, RA area: right atrial area, RVEDD: right ventricular end diastolic diameter, TAPSE: Tricuspid annular plane systolic excursion.
*
Statistically significant at p ≤ 0.05.