Table 1.
Demographic, Clinical, and Routine CSF Characteristics at Lumbar Puncture and Follow-Up MRI Data
| CIS | RRMS | SPMS | PPMS | All | |
| n | 112 | 90 | 23 | 14 | 239 |
| Demographic and clinical data | |||||
| Female, n (%) | 80 (71.4) | 64 (71.1) | 13 (56.5) | 8 (57.1) | 165 (69) |
| Age at LP (y) | 34.4 (26.7–43.8) | 38.0 (31.4–48.1) | 53.7 (48.9–59.6) | 48.5 (46.7–57.8) | 38.5 (29.7–49.1) |
| EDSS at LP | 2.0 (1.5–2.5) | 2.5 (2.0–3.5) | 6.0 (4.0–7.0) | 3.5 (3.0–4.0) | 2.5 (2.0–3.5) |
| Untreated, n (%) | 111 (99.1) | 70 (77.8) | 15 (65.2) | 13 (92.9) | 209 (87.4) |
| Disease duration at LP (m) | 0.6 (0.3–1.8) | 56.1 (15.6–91.7) | 253.1 (147.0–332.1) | 50.0 (15.2–81.3) | 7.8 (0.7–67.3) |
| McDonald criteria 2017 met at LP, n (%) | 71 (63.4) | 90 (100) | 23 (100) | 14 (100) | 198 (82.8) |
| CSF data | |||||
| Cell count (cells/mcl) | 4.3 (2.0–9.0) | 3.0 (1.0–6.0) | 1.0 (0.3–2.2) | 1.7 (1.1–2.9) | 3.0 (1.3–6.6) |
| Qalb | 4.5 (3.6–6.4) | 5.4 (3.9–7.3) | 5.5 (3.8–7.7) | 5.0 (4.4–7.2) | 5.0 (3.8–6.8) |
| OCGBa (%) | 90 (80.4) | 73 (82.0) | 17 (85.0) | 11 (78.6) | 191 (81.3) |
| IgGIFa (%) | 66 (58.9) | 53 (59.6) | 9 (45.0) | 8 (57.1) | 136 (57.9) |
| IgMIFa (%) | 31 (27.7) | 24 (27.0) | 2 (10.0) | 3 (21.4) | 60 (25.5) |
| IgAIFa (%) | 5 (4.5) | 7 (7.9) | 1 (5.0) | 1 (7.1) | 14 (6.0) |
| MRI data | |||||
| MRI follow-up available, n (%) | 61 (54.5) | 52 (57.8) | 13 (56.5) | 8 (57.1) | 134 (56.1) |
| Follow-up time MRI (mean, SD, y) | 6.9 (3.2) | 7.0 (3.2) | 7.1 (3.2) | 7.2 (4.3) | 7.0 (3.2) |
| MRIs per patient | 7 (6, 9.25) | 8 (5, 9) | 5 (2.75, 8) | 6.5 (3.5, 7.25) | 7 (5, 9) |
Abbreviations: CIS = clinically isolated syndrome; EDSS = Expanded Disability Status Scale Score; Ig G/M/AIF = immunoglobulin G/M/A intrathecal fraction; IQR = interquartile range; LP = lumbar puncture; OCGB = oligoclonal IgG bands; PPMS = primary progressive MS; Qalb = albumin quotient; RRMS = relapsing-remitting MS; SPMS = secondary progressive MS.
Median and IQR are displayed if not mentioned otherwise.
a
Presence of OCGB or IgGIF/IgMIF/IgAIF.