Table 2.

Multivariable Associations of CSF Complement Components and Activation Products With MRI Parameters

	Longitudinal brain atrophy (BPF) n = 829 MRIs/120 pat			Longitudinal total T2-weighted lesion volume n = 930 MRIs/128 pat			CE lesions n = 996 MRIs/133 pat			PRLs n = 101 MRIs/pat
	Est (%)	CI	p Value	ME	CI	p Value	OR	CI	p Value	IRR	CI	p Value
C4a	−0.24	−0.31 to −0.16	<1e-04	1.79	1.23–2.60	0.00292	1.81	0.97–3.36	0.0623	1.52	0.94–2.47	0.0906
C4	−0.05	−0.15 to 0.05	0.3607	0.93	0.59–1.46	0.75055	1.46	0.59–3.60	0.4126	0.75	0.44–1.28	0.2896
C3a	−0.13	−0.21 to −0.06	0.00024	2.19	1.58–3.04	<1e-04	2.54	1.40–4.61	0.00224	2.58	1.66–4.03	<0.01
C3	−0.12	−0.16 to −0.07	<1e-04	1.14	0.92–1.41	0.22440	1.26	0.88–1.82	0.2041	1.16	0.90–1.49	0.2605
C5a	−0.07	−0.11 to −0.04	<1e-04	1.16	0.98–1.38	0.07889	1.40	1.03–1.91	0.03323	1.25	1.03–1.52	0.0264
s-C5b9	−0.06	−0.09 to −0.03	<1e-04	1.20	1.04–1.38	0.01415	1.23	0.92–1.64	0.1550	1.17	0.98–1.40	0.0863
C5	−0.07	−0.13 to −0.01	0.0332	0.82	0.56–1.21	0.31617	0.68	0.31–1.49	0.3360	0.59	0.35–1.00	0.0518
Ba	−0.22	−0.29 to −0.15	<1e-04	1.97	1.26–3.08	0.00376	3.32	1.53–7.21	0.00240	2.33	1.27–4.26	<0.01
Bb	−0.12	−0.17 to −0.07	<1e-04	1.15	0.85–1.56	0.35397	1.51	0.89–2.57	0.1263	1.30	0.90–1.86	0.1609
C1q	+0.05	0.10 to 0.19	0.5141	0.78	0.42–1.47	0.44894	0.91	0.31–2.66	0.8674	0.51	0.24–1.10	0.0878
Factor H	−0.13	−0.31 to 0.06	0.1714	1.00	0.35–2.87	0.99970	0.64	0.08–5.28	0.6809	2.85	0.63–12.86	0.173
Factor I	−0.05	−0.13 to 0.03	0.24133	1.17	0.72–1.90	0.51989	0.95	0.41–2.23	0.9121	1.72	0.93–3.19	0.0826

Abbreviations: BPF = brain parenchymal fraction; CAP = complement activation product; CC = complement component; CE = contrast-enhancing; Est. = estimate; IRR = incidence rate ratio; ME = multiplicative effect; OR = odds ratio; pat = patients; PRLs = paramagnetic rim lesions.

Reading example: effect of CC/CAP concentration doubling: per doubling of CSF C3a levels longitudinal total T2-weighted lesion volume is 119% higher.