Table 3.

Multivariable Associations of CSF Complement Components and Activation Products With GFAP and Cytokine Levels in CSF

n = 235	GFAP			CXCL-13			CXCL-9			IL-12b
	ME	CI	p Value	ME	CI	p Value	ME	CI	p Value	ME	CI	p Value
C4a	1.14	1.05–1.25	0.0021	1.63	1.21–2.19	0.0014	1.50	1.23–1.82	<1e-04	1.38	1.17–1.64	0.0003
C4	1.00	0.89–1.13	0.9629	0.60	0.40–0.90	0.0146	0.81	0.62–1.07	0.1422	0.72	0.57–0.92	0.0083
C3a	1.17	1.09–1.26	<1e-04	2.12	1.65–2.70	<1e-04	1.85	1.59–2.16	<1e-04	1.79	1.57–2.04	<1e-04
C3	1.02	0.97–1.07	0.4313	1.21	1.03–1.43	0.0252	1.11	0.99–1.24	0.0628	1.05	0.95–1.16	0.3036
C5a	0.98	0.95–1.02	0.3536	1.21	1.06–1.38	0.0042	1.12	1.03–1.22	0.0086	1.09	1.01–1.18	0.0235
s-C5b9	0.98	0.95–1.02	0.3029	1.14	1.01–1.29	0.0328	1.11	1.02–1.20	0.0114	1.04	0.97–1.12	0.2488
C5	1.05	0.95–1.15	0.3584	0.98	0.70–1.36	0.8840	1.33	1.07–1.66	0.0101	1.17	0.97–1.42	0.1062
Ba	1.03	0.92–1.14	0.6203	2.29	1.60–3.28	<1e-04	2.07	1.65–2.60	<1e-04	1.73	1.41–2.12	<1e-04
Bb	1.01	0.95–1.07	0.8348	1.42	1.15–1.75	0.0013	1.36	1.18–1.56	<1e-04	1.27	1.12–1.43	0.0002
C1q	1.40	1.22–1.60	<1e-04	2.43	1.49–3.98	0.0005	2.13	1.55–2.94	<1e-04	1.77	1.33–2.35	0.0001
Factor H	1.23	0.97–1.55	0.0824	1.03	0.45–2.35	0.9454	1.26	0.73–2.17	0.4067	0.95	0.59–1.54	0.8429
Factor I	1.11	0.99–1.23	0.0663	1.02	0.70–1.49	0.9204	1.30	1.01–1.66	0.0424	1.12	0.89–1.39	0.3325

Abbreviations: CAP = complement activation product; CC = complement component; DMT = disease-modifying treatment; GFAP = glial fibrillary acidic protein; LP = lumbar puncture; ME = multiplicative effect; Qalb = albumin-quotient.

Reading example: effect of CC/CAP concentration doubling: per doubling of CSF C4a levels CXCL-13 levels are increased by 63% (after adjustment for age, sex, Qalb, and DMT category at LP).