Table 3.
Significantly downregulated histone encoding genes following treatment of THP-1 macrophages with A. veronii AS1 or E. coli K-12.
| Gene Symbol | Gene Name | A. veronii AS1 log2FC (p-adj) | E. coli K-12 log2FC (p-adj) |
|---|---|---|---|
| H1–3 | H1.3 linker histone, cluster member | −1.12 (3.58E–28) | −0.70 (3.27E–13) |
| H2AC13 | H2A clustered histone 13 | −1.03 (4.64E–10) | −0.67 (2.00E–04) |
| H2AC16 | H2A clustered histone 16 | −1.15 (2.44E–08) | −0.80 (6.17E–05) |
| H2AC17 | H2A clustered histone 17 | −1.03 (7.85E–17) | −0.56 (3.55E–06) |
| H2AC4 | H2A clustered histone 4 | −1.43 (6.95E–14) | −0.43 (1.93E–01) |
| H2AC7 | H2A clustered histone 7 | −1.07 (9.34E–08) | −0.67 (8.84E–04) |
| H2BC10a | H2B clustered histone 10 | −1.63 (1.01E–28) | −1.37 (9.29E–19) |
| H2BC13 | H2B clustered histone 13 | −1.01 (5.83E–10) | −0.64 (4.72E–05) |
| H2BC14 | H2B clustered histone 14 | −1.11 (2.60E–12) | −0.72 (3.04E–08) |
| H2BC17 | H2B clustered histone 17 | −1.12 (3.76E–23) | −0.54 (1.95E–06) |
| H2BC6 | H2B clustered histone 6 | −1.03 (8.10E–18) | −0.81 (3.65E–10) |
| H2BC9 | H2B clustered histone 9 | −1.15 (2.68E–17) | −0.97 (8.53E–12) |
| H3C1 | H3 clustered histone 1 | −1.09 (4.24E–09) | −0.97 (4.86E–07) |
| H3C11 | H3 clustered histone 11 | −1.04 (8.48E–07) | −0.70 (1.28E–04) |
| H3C12 | H3 clustered histone 12 | −1.42 (1.02E–16) | −0.99 (1.85E–13) |
| H3C2 | H3 clustered histone 2 | −1.03 (5.71E–18) | −0.73 (2.32E–12) |
| H3C3 | H3 clustered histone 3 | −1.21 (5.10E–35) | −0.91 (1.63E–25) |
| H3C4 | H3 clustered histone 4 | −1.03 (2.72E–12) | −0.79 (3.32E–10) |
| H3C7 | H3 clustered histone 7 | −1.03 (1.44E–4) | −0.34 (4.75E–01) |
| H3C8a | H3 clustered histone 8 | −1.70 (1.49E–18) | −1.15 (2.32E–15) |
| H4C2 | H4 clustered histone 2 | −1.04 (9.50E–08) | −0.35 (1.70E–01) |
| H4C9 | H4 clustered histone 9 | −1.60 (2.36E–19) | −0.87 (2.73E–06) |
aGenes significantly downregulated by both A. veronii AS1 or E. coli K-12 treated THP-1 macrophages.
Twenty-two biologically significantly downregulated histone encoding genes (p-adj <0.05, log2FC ≤ −1) were identified through RNA-seq analysis of THP-1 macrophages treated with A. veronii AS1 or E. coli K-12 for 2 hours. Two of these genes (H3C8 and H2BC10) are significantly downregulated by both bacteria, with 20 only significantly downregulated in A. veronii AS1 treated cells. Gene symbols and names were recorded. The log2FC and p-adj for both bacterial species are recorded and are listed adjacent. Statistical significance was assessed using Wald’s test and then adjusted using the Benjamini–Hochberg method.