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[Preprint]. 2024 Dec 26:2024.12.24.630168. [Version 2] doi: 10.1101/2024.12.24.630168

Figure 6. Differential roles of type I and type II interferons on OPC.

Figure 6.

Oligodendrocyte progenitor cells (OPCs) were cultured from embryonic pups of C57BL/6 mice, following the procedures outlined in the Material and Methods section. The OPCs were then divided into three groups: untreated, treated with 20 ng/ml IFN-β, or treated with 20 ng/ml IFN-γ, respectively, for a duration of 6 hours. Subsequently, mRNA was extracted for Q-PCR analysis.

(A) Depicts the expression of MHC-I-related genes.

(B) Depicts the expression of MHC-II-related genes.

(C) Highlights genes specifically induced by IFN-γ.

(D) Highlights genes specifically induced by IFN-β.

Data are from one experiment representative of three independent experiments, with n=3 technical repeats per group in each experiment. Error bars represent SEM, with ***p<0.001.