Table 3:

Treatment-Emergent Adverse Reactions in Safety Population

Preferred Term	Any Grade	Grade ≥3
Nausea	57 (38)	0
Fatigue/Malaise	55 (36)	2 (1)
Arthralgia*	43 (28)	4 (3)
Constipation	39 (26)	0
Leukocytosis	38 (25)	14 (9)
Dyspnea*	37 (24)	4 (3)
Rash*	36 (24)	2 (1)
Pyrexia	36 (24)	1 (1)
Mucositis	35 (23)	5 (3)
Diarrhea	31 (20)	2 (1)
Transaminitis*	31 (20)	18 (12)
Abdominal Pain	28 (18)	1 (1)
Edema*	27 (18)	4 (3)
Cough*	26 (17)	1 (1)
Differentiation Syndrome	25 (16)	13 (8)
Vomiting	25 (16)	1 (1)
Headache	19 (13)	0
Hypertension*	16 (10)	7 (5)

Source: FDA Data

^*Includes Grouped Terms. See Supplementary Table S1 for more information.